R
R. Blake Hill
Researcher at Medical College of Wisconsin
Publications - 54
Citations - 2656
R. Blake Hill is an academic researcher from Medical College of Wisconsin. The author has contributed to research in topics: Mitochondrion & Mitochondrial fission. The author has an hindex of 21, co-authored 46 publications receiving 2290 citations. Previous affiliations of R. Blake Hill include Johns Hopkins University & Cornell University.
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Journal ArticleDOI
Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membrane.
Matthew G. Vander Heiden,Xiao Xian Li,Eyal Gottleib,R. Blake Hill,Craig B. Thompson,Marco Colombini +5 more
TL;DR: Recombinant Bcl-xL can maintain metabolite exchange across the outer mitochondrial membrane by inhibiting VDAC closure following an apoptotic signal, and when ADP-induced oxidative phosphorylation is limited by exogenous β-NADH, it can sustain outer mitochondrial membranes permeability to ADP.
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The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
Evan A. Bordt,Pascaline Clerc,Brian A. Roelofs,Andrew J. Saladino,Andrew J. Saladino,Laszlo Tretter,Vera Adam-Vizi,Edward Cherok,Ahmed Khalil,Ahmed Khalil,Nagendra Yadava,Nagendra Yadava,Nagendra Yadava,Shealinna X. Ge,T. Chase Francis,Nolan W. Kennedy,Lora K. Picton,Tanya Kumar,Sruti Uppuluri,Alexandrea M. Miller,Kie Itoh,Mariusz Karbowski,Hiromi Sesaki,R. Blake Hill,Brian M. Polster +24 more
TL;DR: It is shown that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e.g., 50 μM) used to target mitochondrial fission.
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Mitochondrial fission proteins regulate programmed cell death in yeast
Yihru Fannjiang,Wen Chih Cheng,Sarah J. Lee,Bing Qi,Jonathan Pevsner,J. Michael McCaffery,R. Blake Hill,Gorka Basañez,J. Marie Hardwick +8 more
TL;DR: Findings indicate that yeast and mammalian cells have a conserved programmed death pathway regulated by a common molecular component, Drp1/Dnm1, that is inhibited by a Bcl-2-like function.
Journal ArticleDOI
The interaction between RTX toxins and target cells.
TL;DR: RTX toxins are important virulence factors produced by a wide range of Gram-negative bacteria and offer interesting models for targeting, insertion and translocation of aqueous proteins into lipid membranes.
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A Lethal de Novo Mutation in the Middle Domain of the Dynamin-related GTPase Drp1 Impairs Higher Order Assembly and Mitochondrial Division
Chuang-Rung Chang,Cara Marie Manlandro,Damien Arnoult,Julia Stadler,Ammon E. Posey,R. Blake Hill,Craig Blackstone +6 more
TL;DR: TheDrp1 A395D lethal defect likely resulted in impaired higher order assembly of Drp1 at mitochondria, leading to decreased fission, elongated mitochondria), and altered cellular distribution of mitochondria.