T
T. Chase Francis
Researcher at University of Maryland, Baltimore
Publications - 24
Citations - 1561
T. Chase Francis is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Nucleus accumbens & Medium spiny neuron. The author has an hindex of 15, co-authored 20 publications receiving 1081 citations. Previous affiliations of T. Chase Francis include National Institute on Drug Abuse.
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Journal ArticleDOI
The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
Evan A. Bordt,Pascaline Clerc,Brian A. Roelofs,Andrew J. Saladino,Andrew J. Saladino,Laszlo Tretter,Vera Adam-Vizi,Edward Cherok,Ahmed Khalil,Ahmed Khalil,Nagendra Yadava,Nagendra Yadava,Nagendra Yadava,Shealinna X. Ge,T. Chase Francis,Nolan W. Kennedy,Lora K. Picton,Tanya Kumar,Sruti Uppuluri,Alexandrea M. Miller,Kie Itoh,Mariusz Karbowski,Hiromi Sesaki,R. Blake Hill,Brian M. Polster +24 more
TL;DR: It is shown that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e.g., 50 μM) used to target mitochondrial fission.
Journal ArticleDOI
Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress
T. Chase Francis,Ramesh Chandra,Danielle M. Friend,Eric Finkel,Genesis Dayrit,Genesis Dayrit,Jorge Miranda,Jorge Miranda,Julie M. Brooks,Sergio D. Iñiguez,Patricio O'Donnell,Alexxai V. Kravitz,Mary Kay Lobo +12 more
TL;DR: It is demonstrated that the frequency of excitatory synaptic input is decreased in D1-MSNs and increased in D2-MSNS in mice displaying depression-like behaviors after CSDS, and bidirectional alteration of D 1-MSN activity promotes opposite behavioral outcomes to chronic social stress.
Journal ArticleDOI
Reward behaviour is regulated by the strength of hippocampus-nucleus accumbens synapses
Tara A. LeGates,Mark D. Kvarta,Jessica R. Tooley,T. Chase Francis,Mary Kay Lobo,Meaghan C. Creed,Scott M. Thompson +6 more
TL;DR: It is concluded that hippocampus–NAc synapses show activity-dependent plasticity and suggest that their strength may be critical for contextual reward behaviour, and dopamine-independent induction of long-term potentiation at hippocampal synapses onto the nucleus accumbens modulates reward-related behaviour.
Journal ArticleDOI
Emerging Role for Nucleus Accumbens Medium Spiny Neuron Subtypes in Depression.
T. Chase Francis,Mary Kay Lobo +1 more
TL;DR: Current understanding about the role of nucleus accumbens MSN subtypes in stress-related depression behavior is addressed and how currently understood mechanisms contribute to factors that control the activity of MSNs are speculated on.
Journal ArticleDOI
Opposing Role for Egr3 in Nucleus Accumbens Cell Subtypes in Cocaine Action
Ramesh Chandra,T. Chase Francis,Prasad Konkalmatt,Ariunzaya Amgalan,Amy M. Gancarz,David M. Dietz,Mary Kay Lobo +6 more
TL;DR: Novel insight is provided into an opposing role of Egr3 in select NAc MSN subtypes in cocaine action and repeated cocaine administration altered EGr3 binding to promoters of genes that are important for cocaine-mediated cellular and behavioral plasticity.