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Brian M. Polster
Researcher at University of Maryland, Baltimore
Publications - 64
Citations - 4467
Brian M. Polster is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Mitochondrion & Mitochondrial apoptosis-induced channel. The author has an hindex of 32, co-authored 56 publications receiving 3838 citations. Previous affiliations of Brian M. Polster include Buck Institute for Research on Aging & Johns Hopkins University.
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Journal ArticleDOI
Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria
Brian M. Polster,Brian M. Polster,Gorka Basañez,Aitor Etxebarria,J. Marie Hardwick,David G. Nicholls +5 more
TL;DR: A novel mechanism of AIF release involving calpain processing is defined and a potential molecular checkpoint for cytoprotective interventions is identified that is identified in vivo following acute rodent brain injuries.
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Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria
Hong Wang,Urmilla Sreenivasan,Hong Hu,Andrew J. Saladino,Brian M. Polster,Linda M. Lund,Da-Wei Gong,William C. Stanley,Carole Sztalryd +8 more
TL;DR: Results suggest that Plin5 regulates oxidative LD hydrolysis and controls local FA flux to protect mitochondria against excessive exposure to FA during physiological stress.
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The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species
Evan A. Bordt,Pascaline Clerc,Brian A. Roelofs,Andrew J. Saladino,Andrew J. Saladino,Laszlo Tretter,Vera Adam-Vizi,Edward Cherok,Ahmed Khalil,Ahmed Khalil,Nagendra Yadava,Nagendra Yadava,Nagendra Yadava,Shealinna X. Ge,T. Chase Francis,Nolan W. Kennedy,Lora K. Picton,Tanya Kumar,Sruti Uppuluri,Alexandrea M. Miller,Kie Itoh,Mariusz Karbowski,Hiromi Sesaki,R. Blake Hill,Brian M. Polster +24 more
TL;DR: It is shown that mdivi-1 reversibly inhibits mitochondrial complex I-dependent O2 consumption and reverse electron transfer-mediated reactive oxygen species (ROS) production at concentrations (e.g., 50 μM) used to target mitochondrial fission.
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Mitochondrial mechanisms of neural cell apoptosis
Brian M. Polster,Gary Fiskum +1 more
TL;DR: The evidence for various release mechanisms of apoptotic proteins (e.g. cytochrome c) from neural cell mitochondria are discussed, focusing particularly on roles for calcium, Bax, p53, and oxidative stress.
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Mitochondrial Mechanisms of Neural Cell Death and Neuroprotective Interventions in Parkinson's Disease
TL;DR: Advances in the knowledge of mitochondrial cell death mechanisms and their inhibitors may lead to neuroprotective interventions applicable to Parkinsons's disease.