R
R. Ileng Kumaran
Researcher at Cold Spring Harbor Laboratory
Publications - 5
Citations - 744
R. Ileng Kumaran is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Regulation of gene expression & Lamin. The author has an hindex of 5, co-authored 5 publications receiving 715 citations. Previous affiliations of R. Ileng Kumaran include Centre for Cellular and Molecular Biology.
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A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence
TL;DR: An inducible system to target a genetic locus to the nuclear lamina in living mammalian cells using three-dimensional time-lapse microscopy is presented, determining that targeting of the locus requires passage through mitosis.
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Chromatin Dynamics and Gene Positioning
TL;DR: The current understanding of the dynamics of the interphase genome and how it impacts nuclear organization and gene activity is discussed.
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Lamin A/C speckles mediate spatial organization of splicing factor compartments and RNA polymerase II transcription.
TL;DR: A unique role for lamin speckles is suggested in the spatial organization of RNA splicing factors and pol II transcription in the nucleus by removing the reversible inhibitor DRB and observing a close association between lamin Speckles and SFCs.
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Receptor-mediated delivery of engineered nucleases for genome modification
Zhong Chen,Lahcen Jaafar,Davies G. Agyekum,Haiyan Xiao,Marlene F. Wade,R. Ileng Kumaran,David L. Spector,Gang Bao,Matthew H. Porteus,William S. Dynan,Steffen E. Meiler +10 more
TL;DR: A method for ligand-mediated delivery of zinc finger nucleases (ZFN) proteins using transferrin receptor-mediated endocytosis is demonstrated, showing that transferrin-mediated ZFN uptake leads to site-specific in situ cleavage of the target locus.
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Lamin A/C Haploinsufficiency Modulates the Differentiation Potential of Mouse Embryonic Stem Cells
TL;DR: The results implicate lamin A/C level as an important determinant of lineage-specific differentiation during embryonic development as well as significant effects on embryonic stem cell differentiation to visceral endoderm, neuronal and myogenic lineages upon depletion of lamin C/C.