Rachel Hills

TL;DR: The clinical relevance of the findings is substantiated by the discovery of homozygous PARKIN (PARK2) p.S65N mutations in two unrelated patients with PD and biochemical and structural analysis demonstrates that the ParkinS 65N/S65n mutant is pathogenic and cannot be activated by PINK1.

TL;DR: It is shown that Ser517 O-GlcNAcylation of the microtubule-binding protein Collapsin Response Mediator Protein-2 (CRMP2) increases with age and leads to a small decrease in body weight and mild memory impairment, suggesting that Ser516 O- GlcNA Cylation has a small but detectable impact on mouse physiology and cognitive function.

TL;DR: In this paper, the authors showed that the risk of graft-induced dyskinesias (GIDs) can be induced in rats by hESC-derived dopamine grafts and can occur independently of both previous levodopa exposure and grafted serotonin neurons.

TL;DR: In this paper , the authors evaluated the efficacy of iPSC-DA neuron precursors from two individuals with sporadic PD by transplantation into a hemiparkinsonian rat model after differentiation for either 18 (d18) or 25 days (d25).

TL;DR: It is demonstrated for the first time that graft-host integration, and not DA neuron content, is key to graft-induced functional recovery in Parkinson’s disease patients.