R
Raja Sekhar Nirujogi
Researcher at University of Dundee
Publications - 44
Citations - 3157
Raja Sekhar Nirujogi is an academic researcher from University of Dundee. The author has contributed to research in topics: Phosphorylation & Kinase. The author has an hindex of 11, co-authored 35 publications receiving 2417 citations. Previous affiliations of Raja Sekhar Nirujogi include Pondicherry University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson’s disease in midbrain dopaminergic neurons
Gurvir S. Virdi,Minee L. Choi,James R Evans,Zhi Yao,Dilan Athauda,Stephanie Strohbuecker,Raja Sekhar Nirujogi,Anna I. Wernick,Noelia Pelegrina-Hidalgo,C. C. Leighton,Rebecca Sonia Saleeb,Olga Kopach,Haya Alrashidi,Daniela Melandri,Jimena Perez-Lloret,Plamena R. Angelova,Sergiy Sylantyev,Simon Eaton,Simon J.R. Heales,Dmitri A. Rusakov,Dario R. Alessi,Tilo Kunath,Mathew H. Horrocks,Andrey Y. Abramov,Rickie Patani,Sonia Gandhi +25 more
TL;DR: In this article , a small molecule-based protocol was used to generate highly enriched midbrain dopaminergic (mDA) neurons: molecular identity was confirmed using single-cell RNA sequencing and proteomics, and functional identity was established through dopamine synthesis and measures of electrophysiological activity.
Posted ContentDOI
PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins
Kerryn Berndsen,Pawel Lis,Wondwossen M Yeshaw,Paulina S. Wawro,Raja Sekhar Nirujogi,Melanie Wightman,Thomas Macartney,Mark Dorward,Axel Knebel,Francesca Tonelli,Suzanne R. Pfeffer,Dario R. Alessi +11 more
TL;DR: PPM1H acts as a key modulator of LRRK2 signaling by controlling dephosphorylation of Rab proteins, and could offer a new therapeutic approach to prevent or treat Parkinson’s disease.
Peer ReviewDOI
Author response: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Martin Steger,Federico Diez,Herschel S. Dhekne,Pawel Lis,Raja Sekhar Nirujogi,Ozge Karayel,Francesca Tonelli,Terina N. Martinez,Esben Lorentzen,Suzanne R. Pfeffer,Dario R. Alessi,Matthias Mann +11 more
Journal ArticleDOI
Very long-chain acyl-CoA synthetase 3 mediates onco-sphingolipid metabolism in malignant glioma
Elizabeth Kolar,Xiaohai Shi,Emily M Clay,Ann B. Moser,Ann B. Moser,Bachchu Lal,Bachchu Lal,Raja Sekhar Nirujogi,Akhilesh Pandey,Veera Venkata Ratnam Bandaru,John Laterra,John Laterra,Zhengtong Pei,Zhengtong Pei,Paul A. Watkins,Paul A. Watkins +15 more
TL;DR: It is concluded that ACSVL3 supports the malignant behavior of U87MG cells, at least in part, by altering cellular sphingolipid metabolism.
Journal ArticleDOI
PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain
Asad U. Malik,Athanasios Karapetsas,Raja Sekhar Nirujogi,Deep Chatterjee,Toan K. Phung,Mel Wightman,Robert Gourlay,Nick Morrice,Sebastian Mathea,Stefan Knapp,Dario R. Alessi +10 more
TL;DR: It is demonstrated that phosphorylation and activation of LRRK1 in HEK293 cells is blocked by PKC inhibitors including LXS-196 (Darovasertib), a compound that has entered clinical trials and reveals a novel unexpected activation mechanism.