R
Randall T. Moon
Researcher at University of Washington
Publications - 305
Citations - 54792
Randall T. Moon is an academic researcher from University of Washington. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 119, co-authored 305 publications receiving 51964 citations. Previous affiliations of Randall T. Moon include Marine Biological Laboratory & Howard Hughes Medical Institute.
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Journal ArticleDOI
Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin.
Randall T. Moon,A P McMahon +1 more
TL;DR: Additional heterogeneity in fibroblast alpha-spectrin near the carboxyl-terminal end is reported, suggesting that fibroblasts express functionally distinct isoforms of nonerythroid alpha-Spectrin.
Journal ArticleDOI
AKT kinase activity is required for lithium to modulate mood-related behaviors in mice.
Jen Q. Pan,Michael C. Lewis,Josh Ketterman,Elizabeth L. Clore,Misha M. Riley,Keenan R Richards,Erin Berry-Scott,Xiulin Liu,Florence F. Wagner,Edward B. Holson,Rachael L. Neve,Travis L. Biechele,Randall T. Moon,Edward M. Scolnick,Tracey L. Petryshen,Tracey L. Petryshen,Stephen J. Haggarty,Stephen J. Haggarty +17 more
TL;DR: This work modeled lithium responsiveness using cellular assays of glycogen synthase kinase 3 (GSK-3) signaling and mood-related behavioral assays in inbred strains of mice that differ in their response to lithium, and distinguished the mechanism of action of lithium from direct GSK-3 inhibition both in vivo and in vitro.
Journal ArticleDOI
WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma
Michael D. Arensman,Anne N. Kovochich,Rima M. Kulikauskas,Anna R. Lay,Pei-Tzu Yang,Xin-Min Li,Timothy R. Donahue,Michael B. Major,Randall T. Moon,Andy J. Chien,David W. Dawson +10 more
TL;DR: The findings indicate WNT7B can serve as a primary determinant of differential Wnt/β-catenin activation in PDAC and other cancer contexts where Wnt activation is mediated by ligand expression rather than mutations in canonical pathway members.
Journal ArticleDOI
Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein
Nathan D. Camp,Richard G. James,David W. Dawson,Feng Yan,James M. Davison,Scott A. Houck,Xiaobo Tang,Ning Zheng,Michael B. Major,Randall T. Moon +9 more
TL;DR: This study reports that WTX interacts with a second ubiquitin ligase adaptor, KEAP1, which functions to regulate the ubiquitination of the transcription factor NRF2, a key control point in the antioxidant response.
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The Tuberin-Hamartin Complex Negatively Regulates β-Catenin Signaling Activity
TL;DR: The data suggest that hamartin and tuberin negatively regulate β-catenin stability and activity by participating in the β-Catenin degradation complex.