R
Randall T. Moon
Researcher at University of Washington
Publications - 305
Citations - 54792
Randall T. Moon is an academic researcher from University of Washington. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 119, co-authored 305 publications receiving 51964 citations. Previous affiliations of Randall T. Moon include Marine Biological Laboratory & Howard Hughes Medical Institute.
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Journal ArticleDOI
Hematopoietic stem cell biology: too much of a Wnt thing.
TL;DR: Wnt signaling has been shown to be involved in stem cell regulation and may represent a key pathway in controlling hematopoiesis.
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WLS inhibits melanoma cell proliferation through the β-catenin signalling pathway and induces spontaneous metastasis
Pei-Tzu Yang,Jamie N. Anastas,Rachel A. Toroni,Michi M. Shinohara,Jamie M. Goodson,Anja K. Bosserhoff,Andy J. Chien,Randall T. Moon +7 more
TL;DR: WLS functions as a negative regulator of melanoma proliferation and spontaneous metastasis by activating WNT/β‐catenin signalling, and is decreased in both melanoma cell lines and in patient tumours relative to skin and to benign nevi.
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Identification of a calcium-dependent calmodulin-binding domain in Xenopus membrane skeleton protein 4.1.
TL;DR: Results of this calmodulin binding activity suggest a possible regulatory mechanism by which calcium and Calmodulin may affect the function of protein 4.1 during development.
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Adhesion Of Acute Myeloid Leukemia Blasts To E-Selectin In The Vascular Niche Enhances Their Survival By Mechanisms Such As Wnt Activation
Sylvia Chien,Siraj U. Haq,Matthew R. Pawlus,Randall T. Moon,Elihu H. Estey,Frederick R. Appelbaum,Megan Othus,John L. Magnani,Pamela S. Becker +8 more
TL;DR: The majority of primary patient acute myeloid leukemia blasts and leukemia stem cells express an E- selectin ligand, as demonstrated by flow cytometry by binding of E-selectin-Fc chimera and by staining by the HECA-452 antibody.
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Identification of a 33-kilodalton cytoskeletal protein with high affinity for the sodium channel.
TL;DR: This study has identified a 33-kilodalton cytoskeletal protein (p33) that binds 32P-labeled sodium channel purified from rat brain and implies that the sodium channel may not be the only ligand for p33.