R
Randall T. Moon
Researcher at University of Washington
Publications - 305
Citations - 54792
Randall T. Moon is an academic researcher from University of Washington. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 119, co-authored 305 publications receiving 51964 citations. Previous affiliations of Randall T. Moon include Marine Biological Laboratory & Howard Hughes Medical Institute.
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Journal ArticleDOI
The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice
Adriana Forero,Jennifer Tisoncik-Go,Tokiko Watanabe,Gongxun Zhong,Masato Hatta,Nicolas Tchitchek,Christian Selinger,Jean Chang,Kristi Barker,Juliet Morrison,Jason D. Berndt,Randall T. Moon,Laurence Josset,Yoshihiro Kawaoka,Michael G. Katze +14 more
TL;DR: It is shown that although both 1918 HA and 1918PB2 are important mediators of efficient viral replication, only 1918 PB2 impacts the pathogenicity of an avian influenza virus sharing high homology to the 1918 pandemic influenza virus.
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Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.
Jennifer J. Trowbridge,Jennifer J. Trowbridge,Borhane Guezguez,Randall T. Moon,Mickie Bhatia +4 more
TL;DR: This study reveals that Wnt3a activates unique cell fate decisions of dormant c‐Kit− that promotes short‐term multilineage reconstitution capacity in vivo, thereby revealing a unique role for Wnt activation in hematopoiesis.
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Wnt signaling induces transcription, spatial proximity, and translocation of fusion gene partners in human hematopoietic cells
Giorgia D. Ugarte,Macarena F. Vargas,Matías A. Medina,Pablo León,David Necuñir,Alvaro A. Elorza,Alvaro A. Elorza,Soraya E. Gutierrez,Randall T. Moon,Alejandra Loyola,Giancarlo V. De Ferrari +10 more
TL;DR: It is reported here that Wnt/β-catenin signaling increases the expression of ETO and RunX1 genes in human hematopoietic progenitors and induces transcription and translocation of RUNX1 and ETO fusion gene partners, opening a novel window to understand the onset/development of leukemia.
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β-catenin gets jaded and von Hippel-Lindau is to blame
TL;DR: Findings provide compelling evidence that Jade-1 ubiquitylates beta-catenin, leading to its degradation, and the loss of VHL, as seen in clear cell renal cell carcinoma, could lead to tumor formation through beta-Catenin de-repression.
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Metabolism as an early predictor of DPSCs aging
Dannie Macrin,Ammar Alghadeer,Yan Ting Zhao,Jason W. Miklas,Abdiasis M. Hussein,Damien Detraux,Aaron M. Robitaille,Anup Madan,Randall T. Moon,Yuliang Wang,Arikketh Devi,Arikketh Devi,Julie Mathieu,Hannele Ruohola-Baker +13 more
TL;DR: Using metabolic flux analysis, this study identifies Barx1 as a DPSCs marker and dissects the first predictive metabolic signature for DPSCs aging, indicating a loss of stem cell characteristics and spontaneous initiation of terminal differentiation.