R
Randall T. Moon
Researcher at University of Washington
Publications - 305
Citations - 54792
Randall T. Moon is an academic researcher from University of Washington. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 119, co-authored 305 publications receiving 51964 citations. Previous affiliations of Randall T. Moon include Marine Biological Laboratory & Howard Hughes Medical Institute.
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Synergistic principles of development: overlapping patterning systems in Xenopus mesoderm induction.
TL;DR: It is suggested that mesoderm induction may not be a discrete set of well separated events, but instead may be a process involving partially overlapping signals that produce the same pattern.
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The Sp1-Related Transcription Factors sp5 and sp5-like Act Downstream of Wnt/β-Catenin Signaling in Mesoderm and Neuroectoderm Patterning
Gilbert Weidinger,Christopher J. Thorpe,Katrin Wuennenberg-Stapleton,John Ngai,Randall T. Moon +4 more
TL;DR: It is concluded that sp5 transcription factors mediate the downstream responses to Wnt/beta-catenin signaling in several developmental processes in zebrafish.
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Wnt/β-Catenin Pathway
TL;DR: The Wnt/β-catenin pathway is the best understood Wnt signaling pathway, and its core components are highly conserved during evolution, although tissue-specific or species-specific modifiers of the pathway are likely.
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Hypoxia-Inducible Factors Have Distinct and Stage-Specific Roles during Reprogramming of Human Cells to Pluripotency
Julie Mathieu,Wenyu Zhou,Yalan Xing,Henrik Sperber,Amy Ferreccio,Zsuzsa Agoston,Kavitha T. Kuppusamy,Randall T. Moon,Hannele Ruohola-Baker +8 more
TL;DR: It is shown that this shift occurs early during reprogramming of human cells and requires hypoxia-inducible factors (HIFs) in a stage-specific manner, and the mechanisms underlying the metabolic shifts associated with the acquisition of a pluripotent identity during repprogramming are shed light.
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Positive and Negative Regulation of Muscle Cell Identity by Members of the hedgehog and TGF-β Gene Families
TL;DR: It is proposed that a Hedgehog signal first induces the formation of slow muscle precursor cells, and subsequent Hedgehog and TGF-β signals exert competing positive and negative influences on the development of muscle pioneer cells.