R
Randall T. Moon
Researcher at University of Washington
Publications - 305
Citations - 54792
Randall T. Moon is an academic researcher from University of Washington. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 119, co-authored 305 publications receiving 51964 citations. Previous affiliations of Randall T. Moon include Marine Biological Laboratory & Howard Hughes Medical Institute.
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Journal ArticleDOI
Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling
Peter Hofsteen,Aaron M. Robitaille,Daniel Patrick Chapman,Randall T. Moon,Randall T. Moon,Charles E. Murry +5 more
TL;DR: This work reveals a regulator of cardiac development, Disabled 2, and found that in zebrafish embryos, it negatively regulates WNT/β-catenin signaling to promote cardiomyocyte differentiation, revealing a highly conserved, previously unidentified process relevant for human heart development.
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Assessment of Hypoxia Inducible Factor Levels in Cancer Cell Lines upon Hypoxic Induction Using a Novel Reporter Construct
Wenyu Zhou,Timothy L. Dosey,Travis L. Biechele,Randall T. Moon,Marshall S. Horwitz,Hannele Ruohola-Baker +5 more
TL;DR: A novel HIF reporter construct containing tandem repeats of minimum HIF binding sites upstream of eYFP coding sequence is reported, which has an excellent signal to background ratio and the reporter activity is HIF dependent and directly correlates with HIF protein levels.
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Expression of Wnt10a in the Central Nervous System of Developing Zebrafish
TL;DR: A polymerase chain reaction-derived clone with sequence homology to partial-length shark and salamander Wnt-10a was used to screen a zebrafish cDNA library, yielding a cDNA encoding a full-length Wnt polypeptide.
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Modulation of the β-Catenin Signaling Pathway by the Dishevelled-Associated Protein Hipk1
Sarah H. Louie,Xiao Yong Yang,William H. Conrad,Jeanot Muster,Stephane Angers,Randall T. Moon,Benjamin N.R. Cheyette +6 more
TL;DR: It is suggested that Hipk1 contributes in a complex fashion to Dsh-dependent signaling activities during early vertebrate development, including regulating the transcription of Wnt/β-catenin target genes in the nucleus, possibly in both repressive and activating ways under changing developmental contexts.
Journal ArticleDOI
First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor.
James D. Moody,Shiri Levy,Julie Mathieu,Yalan Xing,Woojin Kim,Woojin Kim,Cheng Dong,Wolfram Tempel,Aaron M. Robitaille,Luke T. Dang,Amy Ferreccio,Damien Detraux,Sonia B. Sidhu,Licheng Zhu,Licheng Zhu,Lauren Carter,Chao Xu,Chao Xu,Cristina Valensisi,Yuliang Wang,R. David Hawkins,Jinrong Min,Randall T. Moon,Randall T. Moon,Stuart H. Orkin,David Baker,David Baker,Hannele Ruohola-Baker +27 more
TL;DR: The computational design of proteins that bind to the EZH2 interaction site on EED with subnanomolar affinity in vitro and form tight and specific complexes with EED in living cells are described.