R
Randall T. Moon
Researcher at University of Washington
Publications - 305
Citations - 54792
Randall T. Moon is an academic researcher from University of Washington. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 119, co-authored 305 publications receiving 51964 citations. Previous affiliations of Randall T. Moon include Marine Biological Laboratory & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells
Richard G. James,Katherine A. Bosch,Rima M. Kulikauskas,Pei-Tzu Yang,Nicholas C. Robin,Rachel A. Toroni,Travis L. Biechele,Jason D. Berndt,Priska D. von Haller,Jimmy K. Eng,Alejandro Wolf-Yadlin,Andy J. Chien,Randall T. Moon +12 more
TL;DR: This study identifies a kinase that inhibits Wnt/β-catenin signaling, a pathway critical to melanoma cell viability, and sensitizes melanoma cells to cell death stimulated by WNT3A.
Journal ArticleDOI
Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
Lorna S. Kategaya,Binita Changkakoty,Travis L. Biechele,William H. Conrad,Ajamete Kaykas,Ramanuj DasGupta,Randall T. Moon +6 more
TL;DR: Loss-of-function studies in Drosophila and zebrafish embryos, as well as human cultured cells, demonstrate that Bili is an evolutionarily conserved antagonist of Wnt/β-catenin signaling.
Journal Article
Overexpression of wild-type and dominant negative mutant vimentin subunits in developing Xenopus embryos.
TL;DR: Exposure to overexpression of wild-type and deletion mutant subunits in most of the cells of embryos did not lead to any detectable morphological or developmental abnormalities, suggesting that the presence and proper regulation of vimentin expression is not essential during the initial stages of embryogenesis in Xenopus.
Book
Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions
Stefan Hoppler,Randall T. Moon +1 more
TL;DR: Reading wnt signaling in development and disease molecular mechanisms and biological functions is also a way as one of the collective books that gives many advantages.
Journal ArticleDOI
Expression and potential functions of G-protein alpha subunits in embryos of Xenopus laevis
TL;DR: Overexpression of the G alpha 0 and G alpha i-1 genes did not inhibit the normal disappearance of the blastocoel during gastrulation, suggesting a role for these G-proteins in regulating this process, and suggest a specific role for the Galpha s subunit in mediating the initial phases of neural induction.