R
Randall T. Moon
Researcher at University of Washington
Publications - 305
Citations - 54792
Randall T. Moon is an academic researcher from University of Washington. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 119, co-authored 305 publications receiving 51964 citations. Previous affiliations of Randall T. Moon include Marine Biological Laboratory & Howard Hughes Medical Institute.
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Journal ArticleDOI
The Promise and Perils of Wnt Signaling Through β-Catenin
TL;DR: The STKE Connections Maps for these pathways provide an important tool in accessing this large body of complex information about Wnt pathways both in canonical terms and at the species level.
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Zebrafish Prickle, a Modulator of Noncanonical Wnt/Fz Signaling, Regulates Gastrulation Movements
TL;DR: The results support the idea that a vertebrate PCP pathway regulates gastrulation movements and suggest that there is overlap between the PCP and Wnt/calcium pathways.
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The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape.
TL;DR: This Wnt pathway was the first described feature of the noncanonical pathway, and as Ca2+ probably plays a key role in the activation of CamKII and PKC, it is named the Wnt/Ca2+ pathway.
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A small molecule inhibitor of β-catenin/cyclic AMP response element-binding protein transcription
Katayoon H. Emami,Cu Nguyen,Hong Ma,Dae Hoon Kim,Kwang Won Jeong,Masakatsu Eguchi,Randall T. Moon,Jia-Ling Teo,Se Woong Oh,Hak Yeop Kim,Sung Hwan Moon,Jong Ryul Ha,Michael G. Kahn +12 more
TL;DR: ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
Journal ArticleDOI
Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling
Yingwei Mao,Xuecai Ge,Xuecai Ge,Xuecai Ge,Christopher Lee Frank,Christopher Lee Frank,Jon M. Madison,Angela N. Koehler,Mary Kathryn Doud,Carlos Tassa,Erin M. Berry,Erin M. Berry,Takahiro Soda,Karun K. Singh,Karun K. Singh,Travis L. Biechele,Travis L. Biechele,Tracey L. Petryshen,Tracey L. Petryshen,Randall T. Moon,Randall T. Moon,Stephen J. Haggarty,Stephen J. Haggarty,Li-Huei Tsai,Li-Huei Tsai,Li-Huei Tsai +25 more
TL;DR: It is demonstrated that suppression of DISC1 expression reduces neural progenitor proliferation, leading to premature cell cycle exit and differentiation and provides a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders.