R
Rasmus Møller
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 12
Citations - 3899
Rasmus Møller is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Virus & Viral entry. The author has an hindex of 9, co-authored 12 publications receiving 2350 citations. Previous affiliations of Rasmus Møller include Wyss Institute for Biologically Inspired Engineering & New York University.
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Journal ArticleDOI
Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
Daniel Blanco-Melo,Benjamin E. Nilsson-Payant,Wen-Chun Liu,Skyler Uhl,Daisy A. Hoagland,Rasmus Møller,Tristan X. Jordan,Kohei Oishi,Maryline Panis,David H. Sachs,Taia T. Wang,Robert E. Schwartz,Jean K. Lim,Randy A. Albrecht,Benjamin R. tenOever +14 more
TL;DR: It is proposed that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.
Journal ArticleDOI
A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics.
Longlong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Yuri Oh,Amanda Jiang,Amanda Jiang,Rasmus Møller,Daisy A. Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Randy A. Albrecht,Wen-Chun Liu,Tristan X. Jordan,Benjamin E. Nilsson-Payant,Ilona Golynker,Justin J. Frere,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Tian Zhang,Roberto Plebani,Roberto Plebani,Mercy Soong,Atiq Nurani,Seongmin Kim,Danni Y. Zhu,Kambez H. Benam,Kambez H. Benam,Girija Goyal,Sarah E. Gilpin,Rachelle Prantil-Baun,Steven P. Gygi,Rani K. Powers,Kenneth E. Carlson,Matthew B. Frieman,Benjamin R. tenOever,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +42 more
TL;DR: In this paper, a microfluidic bronchial-airway-on-a-chip line was used to model the human airway epithelium and pulmonary endothelium to model viral infection, strain-dependent virulence, cytokine production and the recruitment of circulating immune cells.
Journal ArticleDOI
Leveraging the antiviral type I interferon system as a first line of defense against SARS-CoV-2 pathogenicity.
Daisy A. Hoagland,Rasmus Møller,Skyler Uhl,Kohei Oishi,Justin J. Frere,Ilona Golynker,Shu Horiuchi,Maryline Panis,Daniel Blanco-Melo,David H. Sachs,Knarik Arkun,Jean K. Lim,Benjamin R. tenOever +12 more
TL;DR: In this paper, the authors investigated the dynamics of the systemic response to SARS-CoV-2 in hamsters by histological analysis and transcriptional profiling, and they found that the antiviral response with intranasal administration of recombinant IFN-I reduced viral disease, prevented transmission, and lowered inflammation in vivo.
Posted ContentDOI
Human organs-on-chips as tools for repurposing approved drugs as potential influenza and COVID19 therapeutics in viral pandemics
Longlong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Oh,Amanda Jiang,Rasmus Møller,Daisy Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Daniel Blanco-Melo,Daniel Blanco-Melo,Randy A. Albrecht,Wen-Chun Liu,Tristan X. Jordan,Benjamin E. Nilsson-Payant,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Atiq Nurani,Seong Min Kim,Danni Y. Zhu,Kambez H. Benam,Girija Goyal,Sarah E. Gilpin,Rachelle Prantil-Baun,Rani K. Powers,Kenneth R Carlson,Matthew B. Frieman,Benjamin R. tenOever,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +35 more
TL;DR: Human organ-on-a-chip (Organ Chip) microfluidic culture devices lined by a highly differentiated, primary, human lung airway epithelium cultured under an air-liquid interface and fed by continuous medium flow can be used to model virus entry, replication, strain-dependent virulence, host cytokine production, and recruitment of circulating immune cells in response to infection by influenza.
Posted ContentDOI
Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics
Longlong Si,Haiqing Bai,Melissa Rodas,Wuji Cao,Crystal Yuri Oh,Amanda Jiang,Rasmus Møller,Daisy A. Hoagland,Kohei Oishi,Shu Horiuchi,Skyler Uhl,Daniel Blanco-Melo,Randy A. Albrecht,Wen-Chun Liu,Tristan X. Jordan,Benjamin E. Nilsson-Payant,James Logue,Robert Haupt,Marisa McGrath,Stuart Weston,Atiq Nurani,Seongmin Kim,Danni Y. Zhu,Kambez H. Benam,Girija Goyal,Sarah E. Gilpin,Rachelle Prantil-Baun,Rani K. Powers,Kenneth E. Carlson,Matthew B. Frieman,Benjamin R. tenOever,Donald E. Ingber,Donald E. Ingber,Donald E. Ingber +33 more
TL;DR: It is shown that human organ-on-a-chip (Organ Chip) microfluidic culture devices lined by highly differentiated human primary lung airway epithelium and endothelium can be used to model virus entry, replication, strain-dependent virulence, host cytokine production, and recruitment of circulating immune cells in response to infection by respiratory viruses with great pandemic potential.