Mads Grønborg

TL;DR: A model has been constructed that integrates all quantitative data and includes structural models of abundant proteins and, with the exception of the V-ATPase, contains numerous copies of proteins essential for membrane traffic and neurotransmitter uptake.

TL;DR: A screen in oligodendrocytes establishes a Rab family member and its GAPs as regulators of exosome secretion by controlling endocytic vesicle docking with the plasma membrane.

TL;DR: It is concluded that SVs specific for different neurotransmitters share the majority of their protein constituents, with only few vesicle proteins showing preferences that are nonexclusive, thus confirming that the vesicular transporters are the only components essential for defining the neurotransmitter phenotype of a SV.

TL;DR: It is concluded that the core machinery involved in vesicle docking and exocytosis does not show compositional differences between the two types of synapses.

TL;DR: It is shown that FASS isolates intact ultrapure synaptosomes composed of a resealed presynaptic terminal and a postsynaptic density as assessed by light and electron microscopy, which enables high‐resolution biochemical analyses of specific synapse subpopulations in health and disease.