R
Rexford S. Ahima
Researcher at Johns Hopkins University
Publications - 268
Citations - 37768
Rexford S. Ahima is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Leptin & Insulin resistance. The author has an hindex of 80, co-authored 245 publications receiving 34783 citations. Previous affiliations of Rexford S. Ahima include Johns Hopkins University School of Medicine & Harvard University.
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The hormone resistin links obesity to diabetes
Claire M. Steppan,Shannon T. Bailey,Savitha Bhat,Elizabeth J. Brown,Ronadip R. Banerjee,Christopher M. Wright,Hiralben R. Patel,Rexford S. Ahima,Mitchell A. Lazar +8 more
TL;DR: It is shown that adipocytes secrete a unique signalling molecule, which is named resistin (for resistance to insulin), which circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity.
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Role of leptin in the neuroendocrine response to fasting
Rexford S. Ahima,Daniel Prabakaran,Christos S. Mantzoros,Daqing Qu,Bradford B. Lowell,Eleftheria Maratos-Flier,Jeffrey S. Flier +6 more
TL;DR: It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.
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Adipose Tissue as an Endocrine Organ
Rexford S. Ahima,Jeffery S Flier +1 more
TL;DR: The discovery of leptin in the mid-1990s has focused attention on the role of proteins secreted by adipose tissue, which is also involved in the regulation of neuroendocrine and immune function and the metabolic and cardiovascular complications associated with obesity.
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High-fat diet determines the composition of the murine gut microbiome independently of obesity.
Marie A. Hildebrandt,Christian Hoffmann,Scott Sherrill-Mix,Sue A. Keilbaugh,Micah Hamady,Ying-Yu Chen,Rob Knight,Rexford S. Ahima,Frederic D. Bushman,Gary D. Wu +9 more
TL;DR: In this paper, the authors used the phenotype of RELMβ knockout mice to assess the influence of host phenotype, genotype, immune function, and diet on the composition of the human gut microbiome.
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Distributions of leptin receptor mRNA isoforms in the rat brain.
TL;DR: The localization of leptin receptor mRNA in extrahypothalamic sites in the thalamus and cerebellum suggests that leptin may act on specific sensory and motor systems.