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Richard D. Palmiter
Researcher at University of Washington
Publications - 455
Citations - 74646
Richard D. Palmiter is an academic researcher from University of Washington. The author has contributed to research in topics: Dopamine & Gene. The author has an hindex of 141, co-authored 444 publications receiving 69977 citations. Previous affiliations of Richard D. Palmiter include University of Pennsylvania & Howard Hughes Medical Institute.
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen,Theresa A. Zwingman,Susan M. Sunkin,Seung Wook Oh,Hatim A. Zariwala,Hong Gu,Lydia Ng,Richard D. Palmiter,Michael Hawrylycz,Allan R. Jones,Ed S. Lein,Hongkui Zeng +11 more
TL;DR: A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
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The c- myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Jerry M. Adams,A W Harris,Carl A. Pinkert,Lynn M. Corcoran,Warren S. Alexander,Suzanne Cory,Richard D. Palmiter,Ralph L. Brinster +7 more
TL;DR: Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin μ or κ enhancer frequently develop a fatal lymphoma within a few months of birth and constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation.
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Leptin-regulated endocannabinoids are involved in maintaining food intake
Vincenzo Di Marzo,Sravan K. Goparaju,Lei Wang,Lei Wang,Jie Liu,Jie Liu,Sandor Batkai,Sandor Batkai,Zoltán Járai,Filomena Fezza,Grant I. Miura,Richard D. Palmiter,Takayuki Sugiura,George Kunos,George Kunos +14 more
TL;DR: It is shown that following temporary food restriction, CB1 receptor knockout mice eat less than their wild-type littermates, and the CB1 antagonist SR141716A reduces food intake in wild- type but not knockout mice, which indicates that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin.
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Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes
Richard D. Palmiter,Ralph L. Brinster,Robert E. Hammer,Myrna E. Trumbauer,Michael G. Rosenfeld,Neal C. Birnberg,Ronald M. Evans +6 more
TL;DR: A DNA fragment containing the promoter of the mouse metallothionein-I gene fused to the structural gene of rat growth hormone was microinjected into the pronuclei of fertilized mouse eggs, and seven mice developed that carried the fusion gene and six of these grew significantly larger than their littermates.