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Richard L. Ferrero
Researcher at Hudson Institute of Medical Research
Publications - 137
Citations - 9872
Richard L. Ferrero is an academic researcher from Hudson Institute of Medical Research. The author has contributed to research in topics: Helicobacter pylori & Innate immune system. The author has an hindex of 46, co-authored 132 publications receiving 8915 citations. Previous affiliations of Richard L. Ferrero include Monash University, Clayton campus & University of New South Wales.
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Journal ArticleDOI
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Jérôme Viala,Catherine Chaput,Ivo G Boneca,Ana Cardona,Stephen E. Girardin,Anthony P. Moran,Rafika Athman,Sylvie Mémet,Michael R Huerre,Anthony J. Coyle,Peter S. DiStefano,Philippe J. Sansonetti,A Labigne,John Bertin,Dana J. Philpott,Dana J. Philpott,Richard L. Ferrero,Richard L. Ferrero +17 more
TL;DR: It is proposed that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens as well as an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan.
Journal ArticleDOI
Nod-like proteins in immunity, inflammation and disease.
TL;DR: An additional key function of Nod-like receptors is in inflammatory conditions, which has been emphasized by the identification of several different mutations in the genes encoding Nod1, Nod2 and NALP3 that are associated with susceptibility to inflammatory disorders.
Journal ArticleDOI
Immune modulation by bacterial outer membrane vesicles.
TL;DR: The mechanisms through which OMVs induce host pathology or immune tolerance are described, and the development of OMVs as innovative nanotechnologies are discussed.
Journal ArticleDOI
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells
Maria Kaparakis,Lynne Turnbull,Leticia A.M. Carneiro,Stephen Firth,Harold A. Coleman,Helena C. Parkington,Lionel Le Bourhis,Abdulgader Karrar,Jérôme Viala,Johnson Mak,Melanie L. Hutton,John K. Davies,Peter J Crack,Paul J. Hertzog,Dana J. Philpott,Stephen E. Girardin,Cynthia B. Whitchurch,Richard L. Ferrero +17 more
TL;DR: It is proposed that OMVs released by bacteria in vivo may promote inflammation and pathology in infected hosts via a novel mechanism involving outer membrane vesicles (OMVs), whereby Gram‐negative bacteria deliver peptidoglycan to cytosolic NOD1.
Journal ArticleDOI
Nod1-Mediated Innate Immune Recognition of Peptidoglycan Contributes to the Onset of Adaptive Immunity
Jörg H. Fritz,Lionel Le Bourhis,Gernot Sellge,Joao G. Magalhaes,Hafida Fsihi,Thomas A. Kufer,Cathy Collins,Jérôme Viala,Richard L. Ferrero,Stephen E. Girardin,Dana J. Philpott +10 more
TL;DR: Findings show that innate immune sensing of peptidoglycan by Nod1 is key for priming antigen-specific T cell immunity and subsequent antibody responses in vivo and highlights Nod 1 as a key innate immune trigger in the local tissue microenvironment that drives the development of adaptive immunity.