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Anthony P. Moran
Researcher at National University of Ireland, Galway
Publications - 174
Citations - 11904
Anthony P. Moran is an academic researcher from National University of Ireland, Galway. The author has contributed to research in topics: Helicobacter pylori & Campylobacter jejuni. The author has an hindex of 53, co-authored 171 publications receiving 11438 citations. Previous affiliations of Anthony P. Moran include Griffith University & University of Erlangen-Nuremberg.
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Journal ArticleDOI
Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2 IMPLICATIONS FOR CROHN′S DISEASE
Naohiro Inohara,Yasunori Ogura,Ana Fontalba,Olga Gutierrez,F. Pons,Javier Crespo,Koichi Fukase,Seiichi Inamura,Shoichi Kusumoto,Masahito Hashimoto,Simon J. Foster,Anthony P. Moran,Jose L. Fernandez-Luna,Gabriel Núñez +13 more
TL;DR: NOD2 mediates the host response to bacterial muropeptides derived from peptidoglycan, an activity that is important for protection against Crohn's disease and has implications for understanding adjuvant function and effective vaccine development.
Journal ArticleDOI
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
Jérôme Viala,Catherine Chaput,Ivo G Boneca,Ana Cardona,Stephen E. Girardin,Anthony P. Moran,Rafika Athman,Sylvie Mémet,Michael R Huerre,Anthony J. Coyle,Peter S. DiStefano,Philippe J. Sansonetti,A Labigne,John Bertin,Dana J. Philpott,Dana J. Philpott,Richard L. Ferrero,Richard L. Ferrero +17 more
TL;DR: It is proposed that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens as well as an intracellular pathogen-recognition molecule with specificity for Gram-negative peptidoglycan.
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Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition.
Tsuyoshi Tanabe,Tsuyoshi Tanabe,Mathias Chamaillard,Yasunori Ogura,Li Zhu,Su Qiu,Junya Masumoto,Partho Ghosh,Anthony P. Moran,Martina M Predergast,Gerard Tromp,Charlene J. Williams,Naohiro Inohara,Gabriel Núñez +13 more
TL;DR: Systematic mutational analysis of CARD15/NOD2 and NOD1 reveals distinct roles for N‐terminal and C‐ terminal leucine‐rich repeats (LRRs) in the modulation of NOD2 activation and bacterial recognition.
Journal ArticleDOI
Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion
Andra B. Schromm,Klaus Brandenburg,Harald Loppnow,Anthony P. Moran,Michel H. J. Koch,Ernst Th. Rietschel,Ulrich Seydel +6 more
TL;DR: A correlation between a cylindrical molecular shape of lipid A and antagonistic activity was established: IL-6 induction by enterobacterial LPS was inhibited by cylindrically shaped lipid A except for compounds with reduced headgroup charge.
Journal ArticleDOI
Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease
TL;DR: The core oligosaccharides of low-molecular-weight lipopolysaccharide (LPS) of pathogenic Neisseria spp.