R
Rick Gussio
Researcher at National Institutes of Health
Publications - 22
Citations - 720
Rick Gussio is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Tubulin & Microtubule. The author has an hindex of 15, co-authored 22 publications receiving 691 citations. Previous affiliations of Rick Gussio include Science Applications International Corporation & Braunschweig University of Technology.
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Journal ArticleDOI
Comparison of the Activities of the Truncated Halichondrin B Analog NSC 707389 (E7389) with Those of the Parent Compound and a Proposed Binding Site on Tubulin
Donnette A. Dabydeen,James C. Burnett,Ruoli Bai,Pascal Verdier-Pinard,Sarah J. H. Hickford,George R. Pettit,John W. Blunt,Murray H. G. Munro,Rick Gussio,Ernest Hamel +9 more
TL;DR: The model suggests that halichondrin B and NSC 707389 most likely form highly unstable, small aberrant tubulin polymers rather than the massive stable structures observed with vinca alkaloids and antimitotic peptides.
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Anthrax Biosensor, Protective Antigen Ion Channel Asymmetric Blockade
Kelly M. Halverson,Rekha G. Panchal,Tam Luong Nguyen,Rick Gussio,Stephen F. Little,Martin Misakian,Sina Bavari,John J. Kasianowicz +7 more
TL;DR: Electrophysiological measurements demonstrating that full-length LF and EF convert the current-voltage relationship of the heptameric PA63 ion channel from slightly nonlinear to highly rectifying and diode-like at pH 6.6 provides a novel method for characterizing functional toxin interactions.
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2-Substituted paullones: CDK1/cyclin B-inhibiting property and in vitro antiproliferative activity.
Conrad Kunick,Christiane Schultz,Thomas Lemcke,Daniel W. Zaharevitz,Rick Gussio,Ravi K. Jalluri,Edward A. Sausville,Maryse Leost,Laurent Meijer +8 more
TL;DR: The introduction of a 2-cyanoethyl substituent led to a significant enhancement of CDK1/cyclin B inhibiting property and in vitro antiproliferative activity.
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A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease.
James C. Burnett,Dejan Opsenica,Kamaraj Sriraghavan,Rekha G. Panchal,Gordon Ruthel,Ann R. Hermone,Tam Luong Nguyen,Tara Kenny,Douglas Lane,Connor F. McGrath,James J. Schmidt,Jonathan L. Vennerstrom,Rick Gussio,Bogdan A. Šolaja,Sina Bavari +14 more
TL;DR: Four new, potent inhibitors of a structurally diverse small molecule (non-peptidic) inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain (LC) are identified, supporting the structure-based pharmacophore contribution to inhibition.
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Interactions of Halichondrin B and Eribulin with Tubulin
Ruoli Bai,Tam Luong Nguyen,James C. Burnett,Onur Atasoylu,Murray H. G. Munro,George R. Pettit,Amos B. Smith,Rick Gussio,Ernest Hamel +8 more
TL;DR: It is demonstrated that [(3)H]-labeled halichondrin B (HB), a complex, sponge-derived natural product, is bound to and dissociated from tubulin rapidly at one binding site per αβ-heterodimer, with an apparent K(d) of 0.31 μM.