R
Rob Hegele
Researcher at University of Western Ontario
Publications - 8
Citations - 187
Rob Hegele is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Medicine & Hyperintensity. The author has an hindex of 3, co-authored 4 publications receiving 62 citations. Previous affiliations of Rob Hegele include Lawson Health Research Institute.
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Journal ArticleDOI
Allogenic Fecal Microbiota Transplantation in Patients with Nonalcoholic Fatty Liver Disease Improves Abnormal Small Intestinal Permeability: A Randomized Control Trial
Laura J Craven,Adam Rahman,Seema Nair Parvathy,Melanie Beaton,Justin D. Silverman,Karim Qumosani,Irene Hramiak,Rob Hegele,Rob Hegele,Tisha JoyT. Joy,Jon Meddings,Brad L. Urquhart,Ruth Harvie,Charles A. McKenzie,Charles A. McKenzie,Kelly L. Summers,Kelly L. Summers,Gregor Reid,Gregor Reid,Jeremy P. Burton,Jeremy P. Burton,Michael Silverman,Michael Silverman +22 more
TL;DR: FMT did not improve IR as measured by HOMA-IR or hepatic PDFF but did have the potential to reduce small intestinal permeability in patients with NAFLD.
Journal ArticleDOI
RNAi inhibition of angiopoietin-like protein 3 (ANGPTL3) with ARO-ANG3 mimics the lipid and lipoprotein profile of familial combined hypolipidemia
Gerald F. Watts,Christian Schwabe,Russell S. Scott,Patrick Gladding,D. Sullivan,John Richard Baker,P Clifton,James D. Hamilton,Bruce D. Given,J San Martin,Stacey Melquist,Joshua W. Knowles,Ira J. Goldberg,Rob Hegele,Christie M. Ballantyne +14 more
TL;DR: ANGPTL3 inhibition results in lowering of LDL-C and TRLs which may confer protection against CVD in patients with atherogenic mixed dyslipidemia and is well tolerated without serious or severe adverse events or dropouts related to drug.
Journal ArticleDOI
Roundtable on etiology of familial chylomicronemia syndrome.
Journal ArticleDOI
RNA interference targeting apolipoprotein C-III with ARO-APOC3 in healthy volunteers mimics lipid and lipoprotein findings seen in subjects with inherited apolipoprotein C-III deficiency
Christian Schwabe,Russell S. Scott,D. Sullivan,John Richard Baker,P Clifton,James D. Hamilton,Bruce D. Given,J San Martin,Stacey Melquist,Gerald F. Watts,Ira J. Goldberg,Joshua W. Knowles,Rob Hegele,Christie M. Ballantyne +13 more
TL;DR: Initial results using multiple doses of ARO-APOC3 to silence APOC3 expression in HVs are reported, with good tolerability and potential for treating patients with chylomicronemia at risk of pancreatitis.
Journal ArticleDOI
Soluble Epoxide Hydrolase Derived Linoleic Acid Oxylipins, Small Vessel Disease Markers, and Neurodegeneration in Stroke
Di Yu,Nuan Y. Liang,J R Zebarth,Q. Shen,Miracle Ozzoude,Maged Goubran,Jennifer S. Rabin,Joel Ramirez,Christopher J.M. Scott,Fuqiang Gao,Robert Bartha,Sean Symons,Seyyed M. H. Haddad,Donna Kwan,Robert A. Hegele,Jane M. Lawrence-Dewar,Ayman Hassan,Gustavo Saposnik,Yurika Otoki,Krista L. Lanctôt,Mario Masellis,Ameer Y. Taha,Walter Swardfager,Natalie Rashkovan,Sandra E. Black,Agessandro Abrahao,Lorne Zinman,Alisia Bonnick,Richard H. Swartz,Sean P. Symons,Courtney Berezuk,Melissa F. Holmes,Sabrina Adamo,Morris Freedman,Brian Tan,Mojdeh Zamyadi,Stephen R. Arnott,Derek Beaton,Malcolm A. Binns,Pradeep Reddy Raamana,Stephen C. Strother,Kelly M Sunderland,Athena Theyers,Abiramy Uthirakumaran,Brian Levine,Angela K. Troyer,M. Strong,Peter Kleinstiver,Michael Borrie,Elizabeth Finger,Christen Shoesmith,Frederico Pieruccini-Faria,Manuel Montero-Odasso,Yanina Sarquis-Adamson,Alanna D. Black,Jennifer Mandzia,Allison A Dilliott,Rob Hegele,John L. Robinson,Sali M.K. Farhan,Hassan S. Haddad,Nuwan D. Nanayakkara,Guangyong Zou,Stephen H. Pasternak,JB Orange,Angela Roberts,Mandar Jog,Dallas Seitz,D. W. brien,Ying Chen,Brian C. Coe,Douglas P. Munoz,Paula M. McLaughlin,Alicia J. Peltsch,Susan E. Bronskill,Wendy Lou,Sanjeev Kumar,Bruce G. Pollock,Tarek K. Rajji,David F. Tang-Wai,Carmela Tartaglia,Brenda Varriano,Marvin Chum,John Turnbull,Julia Fraser,Bill McIlroy,Benjamin Cornish,Karen Van Ooteghem,Christopher Hudson,Elena Leontieva,Wendy E. Hatch,Faryan Tayyari,S.A. El Defrawy,E. M. Margolin,Efrem D. Mandelcorn,Barry D. Greenberg,Leanne K. Casaubon,Anthony C. Lang,Connie Marras,Andrew Frank,Dar Dowlatshahi,David Grimes,Dennis E. Bulman,John Woulfe,Mahdi Ghani,Demetrios J. Sahlas,Tom Steeves,David G. Munoz,Corinne E. Fischer,Ekaterina Rogaeva,S. Sujanthan,David P. Breen,Roger A. Dixon +112 more
TL;DR: In this article , Linoleic acid markers of cytochrome P450/soluble-epoxide hydrolase activity were associated with small versus large vessel stroke, with small vessel disease markers consistent with blood brain barrier and neurovascular glial disruption, and temporal lobe atrophy.