Justin D. Silverman

TL;DR: Using a variety of statistical and dynamic modeling approaches, the authors estimate that this variant has a 43 to 90% (range of 95% credible intervals, 38 to 130%) higher reproduction number than preexisting variants, and a fitted two-strain dynamic transmission model shows that VOC 202012/01 will lead to large resurgences of COVID-19 cases.

TL;DR: The notion of “reference frames” is defined, which provide deep intuition about the compositional nature of microbiome data, which allow reassessment of published relative abundance data to reveal reproducible microbial changes from standard sequencing output without the need for new assays.

TL;DR: A novel SARS-CoV-2 variant, VOC 202012/01, emerged in southeast England in November 2020 and appears to be rapidly spreading towards fixation as mentioned in this paper.

TL;DR: The PhILR transform is introduced, which incorporates microbial evolutionary models with the isometric log-ratio transform to allow off-the-shelf statistical tools to be safely applied to microbiota surveys and demonstrates that analyses of community-level structure can be applied toPhILR transformed data with performance on benchmarks rivaling or surpassing standard tools.

TL;DR: FMT did not improve IR as measured by HOMA-IR or hepatic PDFF but did have the potential to reduce small intestinal permeability in patients with NAFLD.