F. Boitier

TL;DR: A germline missense substitution in MITF (Mi-E318K) is identified that occurred at a significantly higher frequency in genetically enriched patients affected with melanoma, RCC or both cancers, when compared with controls and provides insights into the link between SUMOylation, transcription and cancer.

TL;DR: This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available and there was little evidence for an association between CDKN2A mutations and NST, but there was a marginally significant association between NST and ARF.

TL;DR: The tight association of MCV with MCC, the clonal pattern ofMCV integration, and the expression of the viral oncoproteins strongly support a causative role for MCV in the tumour process.

TL;DR: It is shown that melanomas during pregnancy frequently harbor fetal cells that have an endothelial phenotype, which is needed to assess whether the fetal contribution to lymphangiogenesis may alter the prognosis of the maternal tumor.

TL;DR: It is not useful to include a positron emission tomography scan in the initial work-up of patients with primary melanoma, even in patients with thick primary melanomas (>4 mm).