P
Per-Henrik Groop
Researcher at University of Helsinki
Publications - 502
Citations - 20886
Per-Henrik Groop is an academic researcher from University of Helsinki. The author has contributed to research in topics: Diabetes mellitus & Type 1 diabetes. The author has an hindex of 73, co-authored 456 publications receiving 17620 citations. Previous affiliations of Per-Henrik Groop include The Heart Research Institute & George Washington University.
Papers
More filters
Journal ArticleDOI
The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes
Per-Henrik Groop,Per-Henrik Groop,Merlin C. Thomas,John Moran,Johan Wadén,Johan Wadén,Lena M. Thorn,Lena M. Thorn,Ville-Petteri Mäkinen,Ville-Petteri Mäkinen,Milla Rosengård-Bärlund,Milla Rosengård-Bärlund,Markku Saraheimo,Markku Saraheimo,Kustaa Hietala,Kustaa Hietala,Outi Heikkilä,Outi Heikkilä,Carol Forsblom,Carol Forsblom +19 more
TL;DR: An independent graded association was observed between the presence and severity of kidney disease and mortality in a large contemporary cohort of individuals with type 1 diabetes, highlighting the clinical and public health importance of chronic kidney diseaseand its prevention in the management of type 2 diabetes.
Journal ArticleDOI
Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis
Jay S. Skyler,George L. Bakris,Ezio Bonifacio,Tamara Darsow,Robert H. Eckel,Leif Groop,Per-Henrik Groop,Per-Henrik Groop,Yehuda Handelsman,Richard A. Insel,Chantal Mathieu,Allison T. McElvaine,Jerry P. Palmer,Alberto Pugliese,Desmond A. Schatz,Jay M. Sosenko,John P.H. Wilding,Robert E. Ratner +17 more
TL;DR: A structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment is recommended.
Journal ArticleDOI
Diabetic kidney disease
Merlin C. Thomas,Michael Brownlee,Katalin Susztak,Kumar Sharma,Karin Jandeleit-Dahm,Sophia Zoungas,Peter Rossing,Per-Henrik Groop,Mark E. Cooper +8 more
TL;DR: What is now known about the molecular pathogenesis of CKD in patients with diabetes and the key pathways and targets implicated in its progression are summarized and the opportunities to develop new interventions through urgently needed investment in dedicated and focused research are explored.
Journal ArticleDOI
Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease
Kumar Sharma,Bethany Karl,Anna V. Mathew,Jon A. Gangoiti,Christina L. Wassel,Rintaro Saito,Minya Pu,Shoba Sharma,Young Hyun You,Lin Wang,Maggie Diamond-Stanic,Maja T. Lindenmeyer,Carol Forsblom,Wei Wu,Joachim H. Ix,Trey Ideker,Jeffrey B. Kopp,Sanjay K. Nigam,Clemens D. Cohen,Per-Henrik Groop,Per-Henrik Groop,Bruce A. Barshop,Loki Natarajan,William L. Nyhan,Robert K. Naviaux +24 more
TL;DR: It is concluded that urine metabolomics is a reliable source for biomarkers of diabetic complications, and the data suggest that renal organic ion transport and mitochondrial function are dysregulated in diabetic kidney disease.
Journal ArticleDOI
Metabolic Syndrome in Type 1 Diabetes: Association with diabetic nephropathy and glycemic control (the FinnDiane study)
Lena M. Thorn,Lena M. Thorn,Carol Forsblom,Carol Forsblom,J. Fagerudd,J. Fagerudd,Merlin C. Thomas,K. Pettersson-Fernholm,K. Pettersson-Fernholm,Markku Saraheimo,Markku Saraheimo,Johan Wadén,Johan Wadén,Mats Rönnback,Mats Rönnback,Milla Rosengård-Bärlund,Milla Rosengård-Bärlund,Clas Göran af Björkesten,Clas Göran af Björkesten,Marja-Riitta Taskinen,Per-Henrik Groop,Per-Henrik Groop +21 more
TL;DR: The metabolic syndrome is a frequent finding in type 1 diabetes and increases with advanced diabetic nephropathy and worse glycemic control, and also increased with worsening creatinine clearance.