J
Joachim H. Ix
Researcher at University of California, San Diego
Publications - 495
Citations - 22497
Joachim H. Ix is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Kidney disease & Renal function. The author has an hindex of 69, co-authored 437 publications receiving 17964 citations. Previous affiliations of Joachim H. Ix include University of California, Berkeley & University of Vermont.
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Journal ArticleDOI
Intensive vs Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged ≥75 Years: A Randomized Clinical Trial.
Jeff D. Williamson,Mark A. Supiano,Mark A. Supiano,William B. Applegate,Dan R. Berlowitz,Dan R. Berlowitz,Ruth C. Campbell,Glenn M. Chertow,Larry J. Fine,William E. Haley,Amret T. Hawfield,Joachim H. Ix,Joachim H. Ix,Dalane W. Kitzman,John B. Kostis,Marie Krousel-Wood,Lenore J. Launer,Suzanne Oparil,Carlos J. Rodriguez,Christianne L. Roumie,Christianne L. Roumie,Ronald I. Shorr,Ronald I. Shorr,Kaycee M. Sink,Virginia G. Wadley,Paul K. Whelton,Jeff Whittle,Jeff Whittle,Nancy Woolard,Jackson T. Wright,Nicholas M. Pajewski +30 more
TL;DR: Among ambulatory adults aged 75 years or older, treating to an SBP target of less than 120 mm Hg compared with an SBp target of more than 140mm Hg resulted in significantly lower rates of fatal and nonfatal major cardiovascular events and death from any cause.
Journal ArticleDOI
Decline in Estimated Glomerular Filtration Rate and Subsequent Risk of End-Stage Renal Disease and Mortality
Josef Coresh,Tanvir Chowdhury Turin,Kunihiro Matsushita,Yingying Sang,Shoshana H. Ballew,Lawrence J. Appel,Hisatomi Arima,Steven J. Chadban,Steven J. Chadban,Massimo Cirillo,Ognjenka Djurdjev,Jamie A. Green,Gunnar H. Heine,Lesley A. Inker,Fujiko Irie,Areef Ishani,Joachim H. Ix,Csaba P. Kovesdy,Csaba P. Kovesdy,Angharad Marks,Takayoshi Ohkubo,Takayoshi Ohkubo,Takayoshi Ohkubo,Varda Shalev,Anoop Shankar,Chi Pang Wen,Chi Pang Wen,Paul E. de Jong,Kunitoshi Iseki,Bénédicte Stengel,Ron T. Gansevoort,Andrew S. Levey +31 more
TL;DR: Declines in estimated GFR smaller than a doubling of serum creatinine concentration occurred more commonly and were strongly and consistently associated with the risk of ESRD and mortality, supporting consideration of lesser declines in Estimated GFR (such as a 30% reduction over 2 years) as an alternative end point for CKD progression.
Journal ArticleDOI
Calcium density of coronary artery plaque and risk of incident cardiovascular events.
Michael H. Criqui,Julie O. Denenberg,Joachim H. Ix,Robyn L. McClelland,Christina L. Wassel,Dena E. Rifkin,J. Jeffrey Carr,Matthew J. Budoff,Matthew A. Allison +8 more
TL;DR: In this paper, the independent associations of CAC volume and CAC density with incident cardiovascular disease (CVD) events were determined, with an independent association with incident CHD, with a hazard ratio (HR) of 1.81 (95% CI, 1.47-2.6) increase, absolute risk increase 6.9 per 1000 person-years.
Journal ArticleDOI
Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease
Kumar Sharma,Bethany Karl,Anna V. Mathew,Jon A. Gangoiti,Christina L. Wassel,Rintaro Saito,Minya Pu,Shoba Sharma,Young Hyun You,Lin Wang,Maggie Diamond-Stanic,Maja T. Lindenmeyer,Carol Forsblom,Wei Wu,Joachim H. Ix,Trey Ideker,Jeffrey B. Kopp,Sanjay K. Nigam,Clemens D. Cohen,Per-Henrik Groop,Per-Henrik Groop,Bruce A. Barshop,Loki Natarajan,William L. Nyhan,Robert K. Naviaux +24 more
TL;DR: It is concluded that urine metabolomics is a reliable source for biomarkers of diabetic complications, and the data suggest that renal organic ion transport and mitochondrial function are dysregulated in diabetic kidney disease.
Journal ArticleDOI
The Associations of Fibroblast Growth Factor 23 and Uncarboxylated Matrix Gla Protein With Mortality in Coronary Artery Disease: The Heart and Soul Study
Benjamin D. Parker,Leon J. Schurgers,Vincent Brandenburg,Robert H. Christenson,Cees Vermeer,Markus Ketteler,Michael G. Shlipak,Mary A. Whooley,Joachim H. Ix +8 more
TL;DR: In outpatients with stable CAD, higher FGF23 and lower ucMGP levels are independently associated with mortality and CVD events.