R
Robert M. Grant
Researcher at University of California, San Francisco
Publications - 466
Citations - 29445
Robert M. Grant is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Pre-exposure prophylaxis & Men who have sex with men. The author has an hindex of 76, co-authored 437 publications receiving 26835 citations. Previous affiliations of Robert M. Grant include University of Colorado Denver & Makerere University.
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Journal ArticleDOI
Whither or wither microbicides
Robert M. Grant,Dean H. Hamer,Thomas J. Hope,Rowena Johnston,Joep M. A. Lange,Michael M. Lederman,Judy Lieberman,Christopher J. Miller,John P. Moore,Donald E. Mosier,Douglas D. Richman,Robert T. Schooley,Marty S. Springer,Ronald S. Veazey,Mark A. Wainberg +14 more
TL;DR: Although new promising strategies are available, there will need to be serious reappraisals of how decisions are made to advance the next generations of candidates into clinical trials, and the use of appropriate animal models in this process will be critical.
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Impaired replication of protease inhibitor-resistant HIV-1 in human thymus.
Cheryl A. Stoddart,Teri Liegler,Fabrizio Mammano,Valerie Linquist-Stepps,Matthew S. Hayden,Steven G. Deeks,Robert M. Grant,François Clavel,Joseph M. McCune +8 more
TL;DR: It is proposed that the inability of PI-resistant HIV-1 to replicate efficiently in thymus contributes to the preservation of CD4+ T-cell counts in patients showing virologic rebound on PI therapy.
Journal ArticleDOI
Differential Persistence of Transmitted HIV-1 Drug Resistance Mutation Classes
Vivek Jain,Maria Cecília Araripe Sucupira,Peter Bacchetti,Wendy Hartogensis,Ricardo Sobhie Diaz,Esper G. Kallas,Esper G. Kallas,Luiz Mario Janini,Teri Liegler,Christopher D. Pilcher,Robert M. Grant,Rodrigo Cortes,Steven G. Deeks,Frederick Hecht +13 more
TL;DR: The rapid replacement of M184V/I mutations is consistent with known fitness costs and suggests a risk for person-to-person propagation, and host and/or viral factors not accounted for by viral load or mutation class are likely influencing mutation replacement.
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Time course of cerebrospinal fluid responses to antiretroviral therapy: evidence for variable compartmentalization of infection.
Silvija I. Staprans,Natalia Marlowe,David V. Glidden,Tatjana Novakovic-Agopian,Robert M. Grant,Melvyn P. Heyes,Francesca T. Aweeka,Steven G. Deeks,Richard W. Price +8 more
TL;DR: Divergent acute-phase viral kinetics in the CSF and plasma, and proportionally greater long-term decrements in CSF HIV-1 RNA in slow early-responders or poor overall plasma responders indicate variable compartmentalization of CSF infection, consistent with a model of two prototypes ofCSF infection.
Journal ArticleDOI
Syphilis predicts HIV incidence among men and transgender women who have sex with men in a preexposure prophylaxis trial.
Marc M. Solomon,Kenneth H. Mayer,Kenneth H. Mayer,David V. Glidden,Albert Y. Liu,Vanessa McMahan,Juan V. Guanira,Suwat Chariyalertsak,Telmo Fernandez,Robert M. Grant +9 more
TL;DR: Syphilis infection was associated with HIV incidence in an HIV-prevention trial that randomized participants to once-daily emtricitabine/tenofovir (FTC/TDF) vs placebo, and syphilis infection did not decrease FTC/ TDF efficacy.