Showing papers by "Robert P. Hasserjian published in 2012"
TL;DR: It is suggested that PFL-like cases also occur in adults and are associated with indolent behavior in this patient population and are characterized by HPI and absence of BCL2 gene abnormality.
113 citations
TL;DR: The results suggest that post-XRT MDS/AML may not represent a direct consequence of radiation toxicity and warrant a therapeutic approach similar to de novo disease.
Abstract: Purpose Therapy-related myeloid neoplasms (t-MN) represent a unique clinical syndrome occurring in patients treated with chemotherapy and/or external-beam radiation (XRT) and are characterized by poorer prognosis compared with de novo disease. XRT techniques have evolved in recent years and are associated with significantly reduced bone marrow exposure. The characteristics of post-XRT t-MN in the current era have not been studied. Patients and Methods We analyzed patients who developed acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) after XRT alone (47 patients) or cytotoxic chemotherapy/combined-modality therapy (C/CMT, 181 patients) and compared them with patients with de novo MDS or AML (222 patients). We estimated bone marrow exposure to radiation and compared the clinical, pathologic, and cytogenetic features and outcome of the XRT patients with the C/CMT patients and with patients with de novo MDS and AML. Results Patients with t-MN after XRT alone had superior overall survival (P = ...
83 citations
TL;DR: An atypical lymphoid infiltrate with numerous MUM1+, CD10−, BCL-6− immunoblasts should raise the suspicion of a reactive process, such as infectious mononucleosis, and warrants additional consideration before a diagnosis of lymphoma is made.
62 citations
TL;DR: Results suggest that CD30 expression on CD8(+) T-cell subsets or plasma levels of soluble CD30 may be a potential biomarker for aGVHD and may also represent a target for novel therapeutic approaches for aGFD.
48 citations
TL;DR: It is suggested that LSC niches in acute and chronic myeloid neoplasms are distinct and differentially modulated by PTH via TGFβ1 and Combinations of TKIs with BMM-modulating agents may be a therapeutic strategy for LSC reduction and cure of CML.
26 citations
TL;DR: The position of neoplastic erythroid proliferations in the current 2008 World Health Organization Classification of Myeloid Neoplasms is examined and recommendations as to how to approach the differential diagnosis of this group of diseases are provided.
22 citations
TL;DR: An 82-year-old man was admitted to this hospital because of a 4-month history of bullous and ulcerated skin lesions on the hands, which did not respond to antibiotic therapy and debridement.
Abstract: An 82-year-old man was admitted to this hospital because of a 4-month history of bullous and ulcerated skin lesions on the hands, which did not respond to antibiotic therapy and debridement. A diagnostic procedure was performed.
9 citations
TL;DR: The recent development of inhibitors of BCR-ABL tyrosine kinase activity have dramatically altered the clinical course of CML, with long-term remissions in most patients treated early in the course of disease.
Abstract: Chronic myelogenous leukemia, BCR-ABL1+ (CML), is a myeloproliferative neoplasm defined by the presence of the BCR-ABL fusion gene produced by the t(9;22)(q32;q11) cytogenetic abnormality. CML manifests clinically as leukocytosis with circulating immature granulocytic precursors and splenomegaly. When untreated, its natural history is that of inexorable progression to an acute leukemia (blast crisis) after a prolonged chronic phase. The recent development of inhibitors of BCR-ABL tyrosine kinase activity have dramatically altered the clinical course of CML, with long-term remissions in most patients treated early in the course of disease.
1 citations
TL;DR: The data suggest that aggressive therapy with SCT should be considered in patients with MDS/AML and inv3/t3 and the revised International Prognostic Scoring System (IPSS-R) includes comprehensive cytogenetic subgrouping to better define prognosis in MDS patients.
1 citations
1 citations