G
Gordana Raca
Researcher at University of Southern California
Publications - 119
Citations - 3217
Gordana Raca is an academic researcher from University of Southern California. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 23, co-authored 88 publications receiving 2232 citations. Previous affiliations of Gordana Raca include University of Wisconsin-Madison & Emory University.
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Journal ArticleDOI
Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen).
Erin Rooney Riggs,Erica F. Andersen,Erica F. Andersen,Athena M. Cherry,Sibel Kantarci,Hutton M. Kearney,Ankita Patel,Gordana Raca,Deborah I. Ritter,Sarah T. South,Erik C. Thorland,Daniel E. Pineda-Alvarez,Swaroop Aradhya,Christa Lese Martin +13 more
TL;DR: A quantitative, evidence-based scoring framework is introduced; the implementation of the five-tier classification system widely used in sequence variant classification is encouraged; and “uncoupling” the evidence- based classification of a variant from its potential implications for a particular individual is recommended.
Journal ArticleDOI
The genomic landscape of hypodiploid acute lymphoblastic leukemia
Linda Holmfeldt,Lei Wei,Ernesto Diaz-Flores,Michael Walsh,Jinghui Zhang,Li Ding,Debbie Payne-Turner,Michelle L. Churchman,Anna Andersson,Shann Ching Chen,Kelly McCastlain,Jared Becksfort,Jing Ma,Gang Wu,Samir Patel,Susan L. Heatley,Letha A. Phillips,Guangchun Song,John Easton,Matthew Parker,Xiang Chen,Michael Rusch,Kristy Boggs,Bhavin Vadodaria,Erin Hedlund,Christina D. Drenberg,Sharyn D. Baker,Deqing Pei,Cheng Cheng,Robert Huether,Charles Lu,Robert S. Fulton,Lucinda Fulton,Yashodhan Tabib,David J. Dooling,Kerri Ochoa,Mark D. Minden,Ian D. Lewis,L. Bik To,Paula Marlton,Andrew W. Roberts,Gordana Raca,Wendy Stock,Geoffrey Neale,Hans G. Drexler,Ross A. Dickins,David W. Ellison,Sheila A. Shurtleff,Ching-Hon Pui,Raul C. Ribeiro,Meenakshi Devidas,Andrew J. Carroll,Nyla A. Heerema,Brent L. Wood,Michael J. Borowitz,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Susana C. Raimondi,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Stephen P. Hunger,Mignon L. Loh,Charles G. Mullighan +63 more
TL;DR: Both near-haploid and low-hypodiploid leukemic cells show activation of Ras-signaling and phosphoinositide 3-kinase (PI3K)-signaling pathways and are sensitive to PI3K inhibitors, indicating that these drugs should be explored as a new therapeutic strategy for this aggressive form of leukemia.
Journal ArticleDOI
Trinucleotide repeats affect DNA replication in vivo.
TL;DR: The results suggest that the formation of unusual DNA structures by trinucleotide repeats in the lagging-strand template may account for the observed replication blockage and have relevance to repeat expansion in humans.
Journal ArticleDOI
A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer.
Alex H. Wagner,Brian Walsh,Georgia Mayfield,David Tamborero,David Tamborero,Dmitriy Sonkin,Kilannin Krysiak,Jordi Deu-Pons,Ryan P Duren,Jianjiong Gao,Julie A. McMurry,Sara E. Patterson,Catherine Del Vecchio Fitz,Beth A. Pitel,Ozman Ugur Sezerman,Kyle Ellrott,Jeremy L. Warner,Damian T. Rieke,Tero Aittokallio,Tero Aittokallio,Ethan Cerami,Deborah I. Ritter,Deborah I. Ritter,Lynn M. Schriml,Robert R. Freimuth,Melissa A. Haendel,Melissa A. Haendel,Gordana Raca,Gordana Raca,Subha Madhavan,Michael Baudis,Jacques S. Beckmann,Rodrigo Dienstmann,Debyani Chakravarty,Xuan Shirley Li,Susan M. Mockus,Olivier Elemento,Nikolaus Schultz,Nuria Lopez-Bigas,Nuria Lopez-Bigas,Mark Lawler,Jeremy Goecks,Malachi Griffith,Obi L. Griffith,Adam A. Margolin +44 more
TL;DR: This community-based project highlights the need for cooperative efforts to curate clinical interpretations of somatic variants for robust practice of precision oncology and develops a framework for harmonizing variant interpretations to produce a meta-knowledgebase.
Journal ArticleDOI
Whole-exome sequencing supports genetic heterogeneity in childhood apraxia of speech
Elizabeth A. Worthey,Gordana Raca,Jennifer Laffin,Brandon Wilk,Jeremy M. Harris,Kathy J. Jakielski,David Dimmock,Edythe A. Strand,Lawrence D. Shriberg +8 more
TL;DR: The first whole-exome sequencing findings from a cohort of 10 unrelated participants with well-characterized CAS are interpreted as support for heterogeneous genetic origins of this pediatric motor speech disorder with multiple genes, pathways and complex interactions.