Robert P. Hasserjian

TL;DR: The TAN-1 gene was originally discovered at the breakpoint of a recurrent chromosomal translocation found in a subset of human T-lymphoblastic leukemias, and tissue distribution and the apparent involvement of an altered version of the gene in T-cell cancers have suggested that T AN-1 normally has some special function in lymphocytes or their precursors.

TL;DR: LG-HPI FL appears to be a subgroup of FL with clinical behavior more akin to grade 3 FL, and should be classified separately from cases of low histologic grade FL with concordantly low PI.

TL;DR: The results suggest that small-molecule tyrosine kinase inhibitors may be effective treatment for activated tyrosINE kinase–mediated malignancies both early in the course of disease and after the development of additional transforming mutations.

TL;DR: A retrospective, multi-institutional study of patients with AEL suggests that AEL is in the continuum of MDS and AML with erythroid hyperplasia, where karyotype rather than an arbitrary blast cutoff represents the most important prognostic factor.

TL;DR: Targeted next-generation sequencing helps to establish clonality in a subset of patients with hypereosinophilia that would otherwise be classified as idiopathic hypereOSinophilic syndrome, and this data suggest that mutation data can be used to establish a diagnosis of chronic eos inophilic leukemia, not otherwise specified in patients presenting with hype reosinphilia.