R
Rolf Kaiser
Researcher at University of Cologne
Publications - 245
Citations - 6846
Rolf Kaiser is an academic researcher from University of Cologne. The author has contributed to research in topics: Drug resistance & Viral load. The author has an hindex of 41, co-authored 230 publications receiving 6213 citations. Previous affiliations of Rolf Kaiser include University of Bonn.
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Bioinformatics prediction of HIV coreceptor usage
TL;DR: As sequencing technology and prediction algorithms improve, HIV genotyping and coreceptor usage prediction are likely to play an increasingly important role in guiding patient prognosis and treatment selection.
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Geno2pheno: estimating phenotypic drug resistance from HIV-1 genotypes
Niko Beerenwinkel,Martin Däumer,Mark Oette,Klaus Korn,Daniel Hoffmann,Rolf Kaiser,Thomas Lengauer,Joachim Selbig,Hauke Walter +8 more
TL;DR: From a set of 650 matched genotype-phenotype pairs, regression models are constructed for the prediction of phenotypic drug resistance from genotypes and standardized measures of resistance are provided that can be calculated from the genotype and are comparable between drugs.
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Diversity and complexity of HIV-1 drug resistance: a bioinformatics approach to predicting phenotype from genotype
Niko Beerenwinkel,Barbara Schmidt,Hauke Walter,Rolf Kaiser,Thomas Lengauer,Daniel Hoffmann,Klaus Korn,Joachim Selbig +7 more
TL;DR: The significance of sequence variations in the protease and reverse transcriptase genes for drug resistance and derived models that predict phenotypic resistance from genotypes are analyzed with a machine learning approach.
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HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
Joshua A. Horwitz,Ariel Halper-Stromberg,Hugo Mouquet,Alexander D. Gitlin,Anna Tretiakova,Thomas Eisenreich,Marine Malbec,Sophia Gravemann,Eva Billerbeck,Marcus Dorner,Hildegard Büning,Olivier Schwartz,Elena Knops,Rolf Kaiser,Michael S. Seaman,James M. Wilson,Charles M. Rice,Alexander Ploss,Pamela J. Bjorkman,Florian Klein,Michel C. Nussenzweig +20 more
TL;DR: It is concluded that immunotherapy reduces plasma viral load and cell-associated HIV-1 DNA and that decreasing the initial viral load enables single bNAbs to control viremia in hu-mice.
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European guidelines on the clinical management of HIV-1 tropism testing
Linos Vandekerckhove,Annemarie M. J. Wensing,Rolf Kaiser,Françoise Brun-Vézinet,Bonaventura Clotet,A. De Luca,A. De Luca,S. Dressler,Federico García,Anna Maria Geretti,Thomas Klimkait,Klaus Korn,Bernard Masquelier,Carlo Federico Perno,Jonathan M. Schapiro,Vincent Soriano,Anders Sönnerborg,Anne-Mieke Vandamme,Chris Verhofstede,Hauke Walter,Maurizio Zazzi,Charles A. Boucher +21 more
TL;DR: The European Consensus Group on clinical management of tropism testing was established to make recommendations to clinicians and clinical virologists recommended an enhanced sensitivity Trofile assay and V3 population genotyping are the recommended methods.