R
Ronald Ramírez-Roa
Researcher at National Autonomous University of Nicaragua
Publications - 4
Citations - 61
Ronald Ramírez-Roa is an academic researcher from National Autonomous University of Nicaragua. The author has contributed to research in topics: Population & Genomics. The author has an hindex of 3, co-authored 4 publications receiving 39 citations.
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Genomic Ancestry, CYP2D6, CYP2C9, and CYP2C19 Among Latin Americans
Fernanda Rodrigues-Soares,Eva M Peñas-Lledó,Eduardo Tarazona-Santos,Martha Sosa-Macías,Enrique Teran,Marisol López-López,Idania Rodeiro,Graciela Moya,Luis R Calzadilla,Ronald Ramírez-Roa,Manuela Grazina,Francisco E Estévez-Carrizo,Ramiro Barrantes,Adrián LLerena,Pharmacogenomics +14 more
TL;DR: The study of a broad spectrum of Native American populations from different ethno‐linguistic groups show how autochthonous diversity shaped the distribution of pharmaco‐alleles and give insights on the prevalence of clinically relevant phenotypes associated with drugs, such as paroxetine, tamoxifen, warfarin, and clopidogrel.
Journal ArticleDOI
Interethnic Variability in CYP2D6, CYP2C9, and CYP2C19 Genes and Predicted Drug Metabolism Phenotypes Among 6060 Ibero- and Native Americans: RIBEF-CEIBA Consortium Report on Population Pharmacogenomics.
M.E.G. Naranjo,Fernanda Rodrigues-Soares,Eva M Peñas-Lledó,Eduardo Tarazona-Santos,Humberto Fariñas,Idania Rodeiro,Enrique Teran,Manuela Grazina,Graciela Moya,Marisol López-López,Alba P Sarmiento,Luis R Calzadilla,Ronald Ramírez-Roa,Rocio Ortiz-Lopez,Francisco E Estévez-Carrizo,Martha Sosa-Macías,Ramiro Barrantes,Adrián LLerena,Pharmacogenomics Ribef +18 more
TL;DR: Pharmacogenetic variation in Latin Americans is understudied, which sets a barrier for the goal of global precision medicine.
Journal ArticleDOI
Challenges and Opportunities for Clinical Pharmacogenetic Research Studies in Resource-limited Settings: Conclusions From the Council for International Organizations of Medical Sciences–Ibero-American Network of Pharmacogenetics and Pharmacogenomics Meeting
Eva M Peñas-Lledó,Enrique Teran,Marta Sosa-Macías,Carlos Galaviz-Hernández,José Pedro Gil,Sujit Nair,Shyam Diwakar,Isabel Hernández,Julio Lara-Riegos,Ronald Ramírez-Roa,Ignacio Verde,Eduardo Tarazona-Santos,Juan Molina-Guarneros,Graciela Moya,Lembit Rägo,Adrián LLerena +15 more
TL;DR: The main result of session 1 was that the pharmacogenetics-related ancestry of the population should be considered when designing clinical studies in RLSs, and the social aspects represent the largest proportion of the challenges and opportunities.
Journal ArticleDOI
Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population.
Fernando de Andrés,Catalina Altamirano-Tinoco,Ronald Ramírez-Roa,Carlos F Montes-Mondragón,Pedro Dorado,Eva M Peñas-Lledó,Adrián LLerena +6 more
TL;DR: The results showed the wide interindividual variability in all the studied enzymes and a significant difference in the activity of CYP1A2 between male and female subjects, thus representing a potential barrier for the clinical implementation of personalized medicine in this region.