R
Ryan C. Gimple
Researcher at University of California, San Diego
Publications - 50
Citations - 3106
Ryan C. Gimple is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Stem cell & Cancer stem cell. The author has an hindex of 18, co-authored 41 publications receiving 1512 citations. Previous affiliations of Ryan C. Gimple include Cleveland Clinic Lerner Research Institute & National Institutes of Health.
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Journal ArticleDOI
Targeting glioma stem cells through combined BMI1 and EZH2 inhibition.
Xun Jin,Xun Jin,Xun Jin,Leo J.Y. Kim,Qiulian Wu,Qiulian Wu,Lisa C. Wallace,Briana C. Prager,Tanwarat Sanvoranart,Ryan C. Gimple,Xiuxing Wang,Xiuxing Wang,Stephen C. Mack,Stephen C. Mack,Tyler E. Miller,Tyler E. Miller,Ping Huang,Claudia L.L. Valentim,Qi Gang Zhou,Jill S. Barnholtz-Sloan,Shideng Bao,Shideng Bao,Shideng Bao,Andrew E. Sloan,Andrew E. Sloan,Jeremy N. Rich +25 more
TL;DR: Combined EZH2 and BMI1 targeting proved more effective than either agent alone both in culture and in vivo, suggesting that strategies that simultaneously target multiple epigenetic regulators within glioblastomas may be effective in overcoming therapy resistance caused by intratumoral heterogeneity.
Journal ArticleDOI
Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer
TL;DR: A review of the most recent evidence regarding the existence of GSCs in glioblastoma tumors and progress made in defining their key molecular regulators is provided.
Journal ArticleDOI
N6-methyladenine DNA Modification in Glioblastoma
Qi Xie,Tao Wu,Ryan C. Gimple,Ryan C. Gimple,Zheng Li,Briana C. Prager,Briana C. Prager,Briana C. Prager,Qiulian Wu,Yang Yu,Pengcheng Wang,Yinsheng Wang,David U. Gorkin,Cheng Zhang,Alexis V. Dowiak,Kaixuan Lin,Chun Zeng,Yinghui Sui,Leo J.Y. Kim,Leo J.Y. Kim,Tyler E. Miller,Li Jiang,Christine Lee,Zhi Huang,Xiaoguang Fang,Kui Zhai,Stephen C. Mack,Maike Sander,Shideng Bao,Amber Kerstetter-Fogle,Amber Kerstetter-Fogle,Andrew E. Sloan,Andrew E. Sloan,Andrew Xiao,Jeremy N. Rich +34 more
TL;DR: The identification of novel N6-methyladenine (N6-mA) DNA modifications in human tissues and implicate this epigenetic mark in human disease, specifically the highly malignant brain cancer glioblastoma, supporting this novel DNA modification as a potential therapeutic target for gliOBlastoma.
Journal ArticleDOI
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Deobrat Dixit,Briana C. Prager,Briana C. Prager,Briana C. Prager,Ryan C. Gimple,Ryan C. Gimple,Hui Xian Poh,Yang Wang,Qiulian Wu,Zhixin Qiu,Reilly L. Kidwell,Leo J.Y. Kim,Leo J.Y. Kim,Qi Xie,Kristoffer Vitting-Seerup,Shruti Bhargava,Zhen Dong,Li Jiang,Zhe Zhu,Petra Hamerlik,Samie R. Jaffrey,Jing Crystal Zhao,Xiuxing Wang,Jeremy N. Rich,Jeremy N. Rich +24 more
TL;DR: YTHDF2 links RNA epitranscriptomic modifications and GSC growth, laying the foundation for the YTHDF 2-MYC-IGFBP3 axis as a specific and novel therapeutic target in glioblastoma.
Journal ArticleDOI
Functional Enhancers Shape Extrachromosomal Oncogene Amplifications
Andrew R. Morton,Nergiz Dogan-Artun,Zachary J Faber,Graham MacLeod,Cynthia F. Bartels,Megan S. Piazza,Kevin C. Allan,Stephen C. Mack,Xiuxing Wang,Ryan C. Gimple,Qiulian Wu,Brian P. Rubin,Shashirekha Shetty,Stephane Angers,Peter B. Dirks,Richard C Sallari,Mathieu Lupien,Jeremy N. Rich,Peter C. Scacheri +18 more
TL;DR: It is indicated that oncogene amplifications are shaped by regulatory dependencies in the non-coding genome, and the pattern of fitness dependencies mirrors the rearrangement of regulatory elements and accompanying rewiring of the chromatin topology on the extrachromosomal amplicon.