P
Petra Hamerlik
Researcher at University of Copenhagen
Publications - 59
Citations - 2338
Petra Hamerlik is an academic researcher from University of Copenhagen. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 19, co-authored 49 publications receiving 1700 citations. Previous affiliations of Petra Hamerlik include Copenhagen University Hospital & Palacký University, Olomouc.
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Journal ArticleDOI
Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
Petra Hamerlik,Justin D. Lathia,Rikke Darling Rasmussen,Qiulian Wu,Jirina Bartkova,MyungHee Lee,Pavel Moudry,Jiri Bartek,Walter Fischer,Jiri Lukas,Jeremy N. Rich +10 more
TL;DR: Autocrine VEGFR2 signaling in glioma stem-like cells evades VEGF neutralization and cell reprograming leads to programmed cell death in patients with gliomas.
Journal ArticleDOI
Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells
David L. Schonberg,Tyler E. Miller,Qiulian Wu,William A. Flavahan,Nupur K. Das,James S. Hale,Christopher G. Hubert,Stephen C. Mack,Awad Jarrar,Robert T. Karl,Ann Mari Rosager,Anne M. Nixon,Paul J. Tesar,Petra Hamerlik,Bjarne Winther Kristensen,Craig Horbinski,James R. Connor,Paul L. Fox,Justin D. Lathia,Jeremy N. Rich +19 more
TL;DR: RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared with tissue-specific progenitors, revealing an iron-regulated CSC pathway.
Journal ArticleDOI
The RNA m6A reader YTHDF2 maintains oncogene expression and is a targetable dependency in glioblastoma stem cells
Deobrat Dixit,Briana C. Prager,Briana C. Prager,Briana C. Prager,Ryan C. Gimple,Ryan C. Gimple,Hui Xian Poh,Yang Wang,Qiulian Wu,Zhixin Qiu,Reilly L. Kidwell,Leo J.Y. Kim,Leo J.Y. Kim,Qi Xie,Kristoffer Vitting-Seerup,Shruti Bhargava,Zhen Dong,Li Jiang,Zhe Zhu,Petra Hamerlik,Samie R. Jaffrey,Jing Crystal Zhao,Xiuxing Wang,Jeremy N. Rich,Jeremy N. Rich +24 more
TL;DR: YTHDF2 links RNA epitranscriptomic modifications and GSC growth, laying the foundation for the YTHDF 2-MYC-IGFBP3 axis as a specific and novel therapeutic target in glioblastoma.
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Analysis of Epithelial and Mesenchymal Markers in Ovarian Cancer Reveals Phenotypic Heterogeneity and Plasticity
Robert Strauss,Zong-Yi Li,Ying Liu,Ines Beyer,Jonas Persson,Pavel Sova,Thomas Möller,Sari Pesonen,Akseli Hemminki,Petra Hamerlik,Charles W. Drescher,Nicole Urban,Jiri Bartek,André Lieber +13 more
TL;DR: The data suggest that E/M-MP cells are able to differentiate into different lineages under certain conditions, and have the capacity for self-renewal, i.e. to maintain a subset of undifferentiated E/Cadherinlow/cytoplasmic E-cadher inhigh/CD133high, CD44high, Tie2low, and the expression levels of Tie2, CD133, and CD44.
Journal ArticleDOI
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas.
J Bartkova,Petra Hamerlik,Marie-Thérése Stockhausen,Jiri Ehrmann,Alice Hlobilkova,Laursen H,Ondrej Kalita,Zdenek Kolar,Hans Skovgaard Poulsen,Helle Broholm,Jiri Lukas,Jiri Bartek +11 more
TL;DR: Results support the potential role of the DDR machinery as a barrier to gliomagenesis and indicate that replication stress, rather than oxidative stress, fuels the DNA damage signalling in early stages of astrocytoma development.