Sabine A. Fuchs

TL;DR: Conditions allowing long-term expansion of adult bile duct-derived bipotent progenitor cells from human liver opens up experimental avenues for disease modeling, toxicology studies, regenerative medicine, and gene therapy.

TL;DR: The presence and important roles of d-amino acids in higher organisms do not only challenge former theories on mammalian physiology, but also contribute to exciting new insights in human disease.

TL;DR: Developing prime editing for primary adult stem cells grown in organoid culture models generates precise in-frame deletions in the gene encoding β‐catenin that result in proliferation independent of Wnt-stimuli, mimicking a mechanism of the development of liver cancer.

TL;DR: Human organoids derived from leucine‐rich repeat‐containing G protein‐coupled receptor 5 (LGR5)–positive adult stem cells represent an exciting new cell source for liver regeneration; however, culturing large numbers of organoids with current protocols is tedious and the level of hepatic differentiation is limited.

TL;DR: A common clinical phenotype is proposed for recessive ARS deficiencies, resulting from insufficient aminoacylation activity to meet translational demand in specific organs or periods of life, assuming residual ARS activity.