S
Sachet A. Shukla
Researcher at Harvard University
Publications - 97
Citations - 44497
Sachet A. Shukla is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Human leukocyte antigen. The author has an hindex of 39, co-authored 89 publications receiving 34805 citations. Previous affiliations of Sachet A. Shukla include Massachusetts Institute of Technology & Broad Institute.
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Journal ArticleDOI
Association of human endogenous retrovirus (hERV) expression with clinical efficacy of PD-1 blockade in metastatic clear cell renal cell carcinoma (mccRCC).
Jean-Christophe Pignon,Opeyemi Jegede,Sachet A. Shukla,David A. Braun,Christine Horak,Megan Wind-Rotolo,Yuko Ishii,Paul J. Catalano,Gordon J. Freeman,Rebecca B. Jennings,Aguirre A. de Cubas,Kimryn Rathmell,Toni K. Choueiri,Michael B. Atkins,David F. McDermott,Sabina Signoretti +15 more
TL;DR: This data indicates that hERV levels positively correlate with tumor immune infiltrate and were recently shown to be associated with clinical benefit to PD-1/PD-L1 blockade in two small cohorts of patients.
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Transcriptomic Correlates of Tumor Cell PD-L1 Expression and Response to Nivolumab Monotherapy in Metastatic Clear Cell Renal Cell Carcinoma.
Thomas Denize,Yue Hou,Jean-Christophe Pignon,Emily Walton,Destiny J West,Gordon J. Freeman,David A. Braun,Catherine J. Wu,Saurabh Gupta,Robert J. Motzer,Michael B. Atkins,David F. McDermott,Toni K. Choueiri,Sachet A. Shukla,Sabina Signoretti +14 more
TL;DR: Both tumor cell-extrinsic and cell proliferation-related mechanisms are likely intertwined in the regulation of TC PD-L1 expression in ccRCC and the quantitation of these transcriptional programs may better predict benefit from anti-PD-1-based therapy.
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Comprehensive molecular characterization and analysis of muscle-invasive urothelial carcinomas.
Seth P. Lerner,Gordon Robertson,Jaegil Kim,Andrew D. Cherniack,Guangwu Guo,Rehan Akbani,Rupa S. Kanchi,Katherine A. Hoadley,Toshinori Hinoue,Peter W. Laird,Hikmat Al-Ahmadie,Joaquim Bellmunt,Mauro A. A. Castro,Dmitry A. Gordenin,Gordon B. Mills,Francisco Sanchez-Vega,Sachet A. Shukla,Ewan A. Gibb,John N. Weinstein,David J. Kwiatkowski +19 more
TL;DR: The entire cohort of 412 tumors from the TCGA project in chemotherapy-naive, muscle-invasive urothelial bladder cancer is reported on, with a high overall somatic mutation rate and APOBEC mutagenesis explained 70% of the mutation burden and was associated with survival.
Journal ArticleDOI
Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer
Zachary Weber,Katharine Collier,David Tallman,Juliet Forman,Juliet Forman,Sachet A. Shukla,Sachet A. Shukla,Sarah Asad,Justin Rhoades,Samuel S. Freeman,Heather A. Parsons,Nicole Williams,Romualdo Barroso-Sousa,Elizabeth H. Stover,Elizabeth H. Stover,Haider Mahdi,Haider Mahdi,Carrie Cibulskis,Niall J. Lennon,Gavin Ha,Viktor A. Adalsteinsson,Sara M. Tolaney,Daniel G. Stover +22 more
TL;DR: In this paper, the authors characterize high-frequency ctDNA sample series collected over narrow time frames from seven patients with metastatic triple-negative breast cancer, each undergoing treatment with Cabozantinib, a multi-tyrosine kinase inhibitor, and evaluate consistency of genomic information from orthogonal assays.
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Cross-site concordance evaluation of tumor DNA and RNA sequencing platforms for the CIMAC-CIDC network
Zexian Zeng,Jingxin Fu,Jingxin Fu,Carrie Cibulskis,Aashna Jhaveri,Curtis Gumbs,Biswajit Das,Beatriz Sanchez-Espiridion,Sylvie Janssens,Len Taing,Jin Wang,Jin Wang,James Lindsay,Tomas Vilimas,Jianhua Zhang,Collin Tokheim,Avinash Das Sahu,Peng Jiang,Chunhua Yan,Dzifa Y. Duose,Ethan Cerami,Li Chen,David Cohen,Qing-Rong Chen,Rebecca A. Enos,Xin Huang,Jack Lee,Yang Liu,Donna Neuberg,Cu Nguyen,Candace Patterson,Sharmistha Sarkar,Sachet A. Shukla,Ming Tang,Junko Tsuji,Mohamed Uduman,Xiaoman Wang,Jason L. Weirather,Jijun Yu,Joyce Yu,Jianjun Zhang,Jiexin Zhang,Daoud Meerzaman,Magdalena Thurin,Andrew Futreal,Chris Karlovich,Stacey Gabriel,Ignacio I. Wistuba,X. Shirley Liu,Catherine J. Wu,Catherine J. Wu,Catherine J. Wu +51 more
TL;DR: In this article, the authors evaluated the consistency of tumor whole-exome (WES) and RNA sequencing (RNA-seq) profiling platforms across different centers, the Cancer Immune Monitoring and Analysis Centers (CIMAC) and the Cancer Immunologic Data Commons (CIDC) conducted a systematic harmonization study.