Sagar

TL;DR: Insight is provided into the endogenous immune system of the central nervous system during development, homeostasis and disease, and may also provide new targets for the treatment of neurodegenerative and neuroinflammatory pathologies.

TL;DR: A transcriptional atlas of myeloid subsets in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, shows that dendritic cells and monocyte-derived cells, but not resident macrophages, played a critical role by presenting antigen to pathogenic T cells, which may inform future therapeutic targeting strategies in MS.

TL;DR: Two high-dimensional technologies are combined, single-cell RNA-sequencing and time-of-flight mass cytometry, to identify and characterize a previously unappreciated spectrum of transcriptional states in human microglia, identifying a spectrum of microglian phenotypes that are determined by localization, aging and glioblastoma.

TL;DR: Cross-reactive and induced SARS-CoV-2-specific CD8 + T cell responses are defined as potentially important determinants of immune protection in mild Sars-Cov-2 infection.

TL;DR: The results indicate that CD8+ T cells are important effector cells, expanded in the early protection window after prime vaccination, precede maturation of other effector arms of vaccine-induced immunity and are stably maintained after boost vaccination.