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Giuseppe Locatelli
Researcher at University of Bern
Publications - 26
Citations - 2078
Giuseppe Locatelli is an academic researcher from University of Bern. The author has contributed to research in topics: Neuroinflammation & Oligodendrocyte. The author has an hindex of 11, co-authored 26 publications receiving 1384 citations. Previous affiliations of Giuseppe Locatelli include Ludwig Maximilian University of Munich & Merck & Co..
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Journal ArticleDOI
Origin, fate and dynamics of macrophages at central nervous system interfaces.
Tobias Goldmann,Peter Wieghofer,Marta Joana Costa Jordão,Fabiola Prutek,Nora Hagemeyer,Kathrin Frenzel,Lukas Amann,Ori Staszewski,Katrin Kierdorf,Martin Krueger,Giuseppe Locatelli,Hannah Hochgerner,Robert Zeiser,Slava Epelman,Frederic Geissmann,Josef Priller,Fabio M.V. Rossi,Ingo Bechmann,Martin Kerschensteiner,Sten Linnarsson,Steffen Jung,Marco Prinz +21 more
TL;DR: Using parabiosis and fate-mapping approaches in mice, it is found that CNS macrophages arose from hematopoietic precursors during embryonic development and established stable populations, with the notable exception of choroid plexus macrophage, which had dual origins and a shorter life span.
Journal ArticleDOI
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
Marta Joana Costa Jordão,Roman Sankowski,Stefanie M. Brendecke,Sagar,Giuseppe Locatelli,Yi-Heng Tai,Tuan Leng Tay,Eva Schramm,Stephan Armbruster,Nora Hagemeyer,Olaf Groß,Dominic Mai,Özgün Çiçek,Thorsten Falk,Martin Kerschensteiner,Dominic Grün,Marco Prinz +16 more
TL;DR: A transcriptional atlas of myeloid subsets in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, shows that dendritic cells and monocyte-derived cells, but not resident macrophages, played a critical role by presenting antigen to pathogenic T cells, which may inform future therapeutic targeting strategies in MS.
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Recent developments of c-Met as a therapeutic target in hepatocellular carcinoma.
Mohamed Bouattour,Eric Raymond,Shukui Qin,Ann-Lii Cheng,Uz Stammberger,Giuseppe Locatelli,Sandrine Faivre +6 more
TL;DR: Preliminary results suggest that selective c‐Met inhibitors have antitumor activity in HCC, with acceptable safety and tolerability in patients with Child‐Pugh A liver function.
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Primary oligodendrocyte death does not elicit anti-CNS immunity
Giuseppe Locatelli,Simone Wörtge,Thorsten Buch,Thorsten Buch,Barbara Ingold,Friederike Frommer,Bettina Sobottka,Martin Krüger,Khalad Karram,Claudia Bühlmann,Ingo Bechmann,Frank L. Heppner,Ari Waisman,Burkhard Becher +13 more
TL;DR: This paper showed that diffuse oligodendrocyte death alone or in conjunction with immune activation does not trigger anti-CNS immunity, and this lack of reactivity was not mediated by enhanced myelin-specific tolerance.
Journal ArticleDOI
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model
Giuseppe Locatelli,Delphine Theodorou,Arek Kendirli,Marta Joana Costa Jordão,Ori Staszewski,Kshiti Phulphagar,Ludovico Cantuti-Castelvetri,Athanasios Dagkalis,Alain Bessis,Mikael Simons,Felix Meissner,Marco Prinz,Marco Prinz,Martin Kerschensteiner +13 more
TL;DR: It is shown that the initial proinflammatory polarization of phagocytes is established after spinal cord entry and critically depends on the compartment they enter, and guided by signals from the CNS environment, individualphagocytes then switch their phenotype as lesions move from expansion to resolution.