S
Stefanie M. Brendecke
Researcher at University of Freiburg
Publications - 20
Citations - 1817
Stefanie M. Brendecke is an academic researcher from University of Freiburg. The author has contributed to research in topics: Microglia & Descending aorta. The author has an hindex of 11, co-authored 20 publications receiving 1374 citations. Previous affiliations of Stefanie M. Brendecke include University Medical Center Freiburg.
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A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
Tobias Goldmann,Peter Wieghofer,Philippe F. Müller,Yochai Wolf,Diana Varol,Simon Yona,Stefanie M. Brendecke,Katrin Kierdorf,Ori Staszewski,Moumita Datta,Tom Luedde,Mathias Heikenwalder,Steffen Jung,Marco Prinz +13 more
TL;DR: A mouse experimental system that specifically targets microglia found TAK1 to be pivotal in CNS autoimmunity, and it is presented as a tool for future investigations of microglial function in the CNS.
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Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
Marta Joana Costa Jordão,Roman Sankowski,Stefanie M. Brendecke,Sagar,Giuseppe Locatelli,Yi-Heng Tai,Tuan Leng Tay,Eva Schramm,Stephan Armbruster,Nora Hagemeyer,Olaf Groß,Dominic Mai,Özgün Çiçek,Thorsten Falk,Martin Kerschensteiner,Dominic Grün,Marco Prinz +16 more
TL;DR: A transcriptional atlas of myeloid subsets in experimental autoimmune encephalomyelitis (EAE), a mouse model of MS, shows that dendritic cells and monocyte-derived cells, but not resident macrophages, played a critical role by presenting antigen to pathogenic T cells, which may inform future therapeutic targeting strategies in MS.
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USP18 lack in microglia causes destructive interferonopathy of the mouse brain
Tobias Goldmann,Nicolas Zeller,Jenni Raasch,Katrin Kierdorf,Kathrin Frenzel,Lars Ketscher,Anja Basters,Ori Staszewski,Stefanie M. Brendecke,Alena Spiess,Tuan Leng Tay,Clemens Kreutz,Jens Timmer,Grazia M.S. Mancini,Thomas Blank,Günter Fritz,Knut Biber,Knut Biber,Roland Lang,Danielle Malo,Doron Merkler,Mathias Heikenwalder,Klaus-Peter Knobeloch,Marco Prinz +23 more
TL;DR: This work identified the ubiquitin‐specific protease (Usp) 18 in white matter microglia that essentially contributes to microglial quiescence and establishes Usp18 as a new molecule preventing destructive microgliopathy.
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Complex Plaques in the Proximal Descending Aorta An Underestimated Embolic Source of Stroke
Andreas Harloff,Jan C. Simon,Stefanie M. Brendecke,Dawit Assefa,Thomas Helbing,Alex Frydrychowicz,Johannes Weber,Manfred Olschewski,Christoph Strecker,Jürgen Hennig,Cornelius Weiller,Michael Markl +11 more
TL;DR: In this paper, the authors investigated the incidence of retrograde flow from complex plaques (4mm-thick, ulcerated, or superimposed thrombi) of the descending aorta and its potential role in embolic stroke.
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Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment.
Thomas Blank,Claudia N. Detje,Alena Spieß,Nora Hagemeyer,Stefanie M. Brendecke,Jakob Wolfart,Ori Staszewski,Tanja Zöller,Ismini Papageorgiou,Justus Schneider,Ricardo Paricio-Montesinos,Ulrich L. M. Eisel,Denise Manahan-Vaughan,Stephan Jansen,Stefan Lienenklaus,Bao Lu,Yumiko Imai,Marcus Müller,Susan E. Goelz,Darren P. Baker,Markus Schwaninger,Oliver Kann,Mathias Heikenwalder,Mathias Heikenwalder,Ulrich Kalinke,Marco Prinz +25 more
TL;DR: This work identified brain endothelial and epithelial cells as natural gatekeepers for virus-induced sickness behavior, demonstrated tissue specific IFNAR engagement, and established the CXCL10-CXCR3 axis as target for the treatment of behavioral changes during virus infection and type I IFN therapy.