Sajesh P. Thomas

TL;DR: A discussion of the FDA guidance on regulatory classification of pharmaceutical cocrystals of active pharmaceutical ingredients (APIs) was held in Manesar near Delhi, India, from February 2-4, 2012 as mentioned in this paper.

TL;DR: This approach is applied to a sample of organic molecular crystals with known bending, shearing and brittle behaviour, to illustrate its use in rationalising their mechanical behaviour at a molecular level.

TL;DR: X-ray charge density analysis provides experimental evidence for this hitherto unexplored 'carbon bonding' interaction and unravels its nature and strength.

TL;DR: Using four different benchmark sets of molecular crystals, the level of confidence for lattice energies estimated using CE-B3LYP model energies and experimental crystal structures is established and it is concluded that they compare very well with available benchmark estimates derived from sublimation enthalpies and in many cases are comparable with and sometimes better than more computationally demanding approaches.

TL;DR: The intriguing observation is reported of plastic bending in dimethyl sulfone, which exhibits nearly isotropic crystal packing and interaction topology, defying the known structural models of bending crystals.