Sajjan Rajpoot

TL;DR: Based on the vesicular cargo, the molecular constituents, the exosomes have the potential to change the fate of macrophage phenotypes, either M1, classically activated macrophages, or M2, alternatively activated macophages.

TL;DR: Design of a novel peptide that could inhibit SARS-CoV-2 spike protein interaction with ACE2, thereby blocking the cellular entry of the virus is designed and suggested that computationally developed inhibitory peptide may be developed as an anti-SARS- covirus disease agent.

TL;DR: This paper proposes the repurposing of the Food and Drug Administration-approved, purchasable, and naturally occurring drugs as a dual-inhibitor for the SARS-CoV-2 cysteine proteases—3Chemotrypsin-like protease or main protease (3CLpro or Mpro) and Papain-likerotease (PLpro)—that are responsible for processing the translated polyprotein chain from the viral RNA-yielding functional viral proteins

TL;DR: In this article, the authors discuss the importance of the TIR domain in TIRAP as a key interface involved in protein interactions which could hence serve as a therapeutic target to dampen the extent of acute and chronic inflammatory conditions.

TL;DR: Thioridazinehydrochloride, a potent antipsychotic drug against Schizophrenia was selected and its efficiency in inhibiting IκBα protein degradation and subsequent NF-κB activation to inhibit inflammation was experimentally validated.