Sakteesh V. Gurunathan

TL;DR: A subset of patients with IBS, especially in PI-IBS, has substantially high faecal PA, greater symptoms, impaired barrier and reduced microbial diversity.

TL;DR: In this article , the compositional, transcriptional and clonotypic landscape of mucosal and circulating B cells were mapped using single-cell RNA sequencing, singlecell IgH gene sequencing and protein-level validation.

TL;DR: Healthy women had lower intestinal permeability and higher duodenal and fecal microbial diversity than healthy men, and Gut microbiota in women is sensitive to perturbation but appears to be more stable in men.

TL;DR: In this paper , the authors demonstrate that overproduction of REG3 proteins can also be detrimental by reducing a protective species in the microbiota and demonstrate that inflammation self-perpetuates by causing aberrant antimicrobial activity that disrupts symbiotic relationships with gut microbes.