S
Samir Patel
Researcher at St. Jude Children's Research Hospital
Publications - 22
Citations - 666
Samir Patel is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 16 publications receiving 578 citations.
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Journal ArticleDOI
The genomic landscape of hypodiploid acute lymphoblastic leukemia
Linda Holmfeldt,Lei Wei,Ernesto Diaz-Flores,Michael Walsh,Jinghui Zhang,Li Ding,Debbie Payne-Turner,Michelle L. Churchman,Anna Andersson,Shann Ching Chen,Kelly McCastlain,Jared Becksfort,Jing Ma,Gang Wu,Samir Patel,Susan L. Heatley,Letha A. Phillips,Guangchun Song,John Easton,Matthew Parker,Xiang Chen,Michael Rusch,Kristy Boggs,Bhavin Vadodaria,Erin Hedlund,Christina D. Drenberg,Sharyn D. Baker,Deqing Pei,Cheng Cheng,Robert Huether,Charles Lu,Robert S. Fulton,Lucinda Fulton,Yashodhan Tabib,David J. Dooling,Kerri Ochoa,Mark D. Minden,Ian D. Lewis,L. Bik To,Paula Marlton,Andrew W. Roberts,Gordana Raca,Wendy Stock,Geoffrey Neale,Hans G. Drexler,Ross A. Dickins,David W. Ellison,Sheila A. Shurtleff,Ching-Hon Pui,Raul C. Ribeiro,Meenakshi Devidas,Andrew J. Carroll,Nyla A. Heerema,Brent L. Wood,Michael J. Borowitz,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Susana C. Raimondi,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Stephen P. Hunger,Mignon L. Loh,Charles G. Mullighan +63 more
TL;DR: Both near-haploid and low-hypodiploid leukemic cells show activation of Ras-signaling and phosphoinositide 3-kinase (PI3K)-signaling pathways and are sensitive to PI3K inhibitors, indicating that these drugs should be explored as a new therapeutic strategy for this aggressive form of leukemia.
Journal ArticleDOI
CONSERTING: integrating copy number analysis with structural variation detection
Xiang Chen,Pankaj Gupta,Jianmin Wang,Joy Nakitandwe,Kathryn G. Roberts,James Dalton,Matthew Parker,Samir Patel,Linda Holmfeldt,Debbie Payne,John Easton,Jing Ma,Michael Rusch,Gang Wu,Aman Patel,Suzanne J. Baker,Michael A. Dyer,Sheila A. Shurtleff,Stephen Espy,Stanley Pounds,James R. Downing,David W. Ellison,Charles G. Mullighan,Jinghui Zhang +23 more
TL;DR: Analysis of 43 cancer genomes from both pediatric and adult patients revealed novel oncogenic CNAs, complex rearrangements and subclonal CNAs missed by alternative approaches.
Journal ArticleDOI
Aspirin and Clopidogrel Resistance in Indian Patients with Ischemic Stroke and its Associations with Gene Polymorphisms: A Pilot Study.
TL;DR: In an interim analysis on 65 Indian patients, a significant association was found between CYP2C19*2 and clopidogrel nonresponsiveness and a high proportion of nonresponders to clopIDogrel was identified.