A
Anna Andersson
Researcher at Swedish University of Agricultural Sciences
Publications - 63
Citations - 3489
Anna Andersson is an academic researcher from Swedish University of Agricultural Sciences. The author has contributed to research in topics: Gene & Leukemia. The author has an hindex of 25, co-authored 61 publications receiving 3022 citations. Previous affiliations of Anna Andersson include Agricultural & Applied Economics Association & St. Jude Children's Research Hospital.
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Journal ArticleDOI
The genomic landscape of hypodiploid acute lymphoblastic leukemia
Linda Holmfeldt,Lei Wei,Ernesto Diaz-Flores,Michael Walsh,Jinghui Zhang,Li Ding,Debbie Payne-Turner,Michelle L. Churchman,Anna Andersson,Shann Ching Chen,Kelly McCastlain,Jared Becksfort,Jing Ma,Gang Wu,Samir Patel,Susan L. Heatley,Letha A. Phillips,Guangchun Song,John Easton,Matthew Parker,Xiang Chen,Michael Rusch,Kristy Boggs,Bhavin Vadodaria,Erin Hedlund,Christina D. Drenberg,Sharyn D. Baker,Deqing Pei,Cheng Cheng,Robert Huether,Charles Lu,Robert S. Fulton,Lucinda Fulton,Yashodhan Tabib,David J. Dooling,Kerri Ochoa,Mark D. Minden,Ian D. Lewis,L. Bik To,Paula Marlton,Andrew W. Roberts,Gordana Raca,Wendy Stock,Geoffrey Neale,Hans G. Drexler,Ross A. Dickins,David W. Ellison,Sheila A. Shurtleff,Ching-Hon Pui,Raul C. Ribeiro,Meenakshi Devidas,Andrew J. Carroll,Nyla A. Heerema,Brent L. Wood,Michael J. Borowitz,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Susana C. Raimondi,Elaine R. Mardis,Richard K. Wilson,James R. Downing,Stephen P. Hunger,Mignon L. Loh,Charles G. Mullighan +63 more
TL;DR: Both near-haploid and low-hypodiploid leukemic cells show activation of Ras-signaling and phosphoinositide 3-kinase (PI3K)-signaling pathways and are sensitive to PI3K inhibitors, indicating that these drugs should be explored as a new therapeutic strategy for this aggressive form of leukemia.
Journal ArticleDOI
The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.
Anna Andersson,Anna Andersson,Jing Ma,Jianmin Wang,Xiang Chen,Amanda Larson Gedman,Jinjun Dang,Joy Nakitandwe,Linda Holmfeldt,Matthew Parker,John Easton,Robert Huether,Richard W. Kriwacki,Michael Rusch,Gang Wu,Yongjin Li,Heather L. Mulder,Susana C. Raimondi,Stanley Pounds,Guolian Kang,Lei Shi,Jared Becksfort,Pankaj Gupta,Debbie Payne-Turner,Bhavin Vadodaria,Kristy Boggs,Donald Yergeau,Jayanthi Manne,Guangchun Song,Michael N. Edmonson,Panduka Nagahawatte,Lei Wei,C. Cheng,Deqing Pei,Rosemary Sutton,Nicola C. Venn,Albert Chetcuti,Amanda Rush,Daniel Catchpoole,Jesper Heldrup,Thoas Fioretos,Charles Lu,Li Ding,Ching-Hon Pui,Sheila A. Shurtleff,Charles G. Mullighan,Elaine R. Mardis,Richard K. Wilson,Tanja A. Gruber,Jinghui Zhang,James R. Downing +50 more
TL;DR: Infant acute lymphoblastic leukemia (ALL) with MLL rearrangements (MLL-R) represents a distinct leukemia with a poor prognosis and has one of the lowest frequencies of somatic mutations of any sequenced cancer, with the predominant leukemic clone carrying a mean of 1.3 non-silent mutations.
Journal ArticleDOI
An Inv(16)(p13.3q24.3)-encoded CBFA2T3-GLIS2 fusion protein defines an aggressive subtype of pediatric acute megakaryoblastic leukemia.
Tanja A. Gruber,Amanda Larson Gedman,Jinghui Zhang,Cary Koss,Suresh Marada,Huy Q. Ta,Shann Ching Chen,Xiaoping Su,Stacey K. Ogden,Jinjun Dang,Gang Wu,Vedant Gupta,Anna Andersson,Stanley Pounds,Lei Shi,John Easton,Michael I. Barbato,Heather L. Mulder,Jayanthi Manne,Jianmin Wang,Michael Rusch,Swati Ranade,Ramapriya Ganti,Matthew Parker,Jing Ma,Ina Radtke,Li Ding,Li Ding,Giovanni Cazzaniga,Andrea Biondi,Steven M. Kornblau,Farhad Ravandi,Hagop M. Kantarjian,Stephen D. Nimer,Konstanze Döhner,Hartmut Döhner,Timothy J. Ley,Timothy J. Ley,Paola Ballerini,Sheila A. Shurtleff,Daisuke Tomizawa,Souichi Adachi,Yasuhide Hayashi,Akio Tawa,Lee Yung Shih,Der Cherng Liang,Jeffrey E. Rubnitz,Ching-Hon Pui,Elaine R. Mardis,Elaine R. Mardis,Richard K. Wilson,Richard K. Wilson,James R. Downing +52 more
TL;DR: In this article, the authors performed transcriptome sequencing on diagnostic blasts from 14 pediatric patients and validated their findings in a recurrency/validation cohort consisting of 34 pediatric and 28 adult AMKL samples.
Journal ArticleDOI
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
Henrik Lilljebjörn,Rasmus Henningsson,Axel Hyrenius-Wittsten,Linda Olsson,Christina Orsmark-Pietras,Sofia von Palffy,Maria Askmyr,Marianne Rissler,Martin Schrappe,Gunnar Cario,Anders Castor,Cornelis J.H. Pronk,Mikael Behrendtz,Felix Mitelman,Bertil Johansson,Kajsa Paulsson,Anna Andersson,Magnus Fontes,Thoas Fioretos +18 more
TL;DR: This study delineates the fusion gene landscape in a consecutive series of 195 paediatric B-cell precursor acute lymphoblastic leukaemia (BCP ALL) and identifies a subtype characterized by an ETV6-RUNX1-like gene-expression profile and coexisting ETV 6 and IKZF1 alterations.
Journal ArticleDOI
The genomic landscape of core-binding factor acute myeloid leukemias
Zachary J Faber,Xiang Chen,Amanda Larson Gedman,Kristy Boggs,Jinjun Cheng,Jing Ma,Ina Radtke,Jyh Rong Chao,Michael P. Walsh,Guangchun Song,Anna Andersson,Jinjun Dang,Li Dong,Yu Liu,Robert Huether,Zhongling Cai,Heather L. Mulder,Gang Wu,Michael N. Edmonson,Michael Rusch,Chunxu Qu,Yongjin Li,Bhavin Vadodaria,Jianmin Wang,Erin Hedlund,Xueyuan Cao,Donald Yergeau,Joy Nakitandwe,Stanley Pounds,Sheila A. Shurtleff,Robert S. Fulton,Lucinda Fulton,John Easton,Evan Parganas,Ching-Hon Pui,Jeffrey E. Rubnitz,Li Ding,Elaine R. Mardis,Richard K. Wilson,Tanja A. Gruber,Charles G. Mullighan,Richard F. Schlenk,Peter Paschka,Konstanze Döhner,Hartmut Döhner,Lars Bullinger,Jinghui Zhang,Jeffery M. Klco,James R. Downing +48 more
TL;DR: Outside of signaling alterations, RUNX1-RUNX1T1 and CBFB-MYH11 AMLs demonstrated remarkably different spectra of cooperating mutations, while highlighting dramatic differences in the landscapes of cooperate mutations for these related AML subtypes.