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Samuel M. Levi
Researcher at Harvard University
Publications - 14
Citations - 1150
Samuel M. Levi is an academic researcher from Harvard University. The author has contributed to research in topics: Autophagy & Catalysis. The author has an hindex of 8, co-authored 13 publications receiving 911 citations. Previous affiliations of Samuel M. Levi include Pfizer & University of Pennsylvania.
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Journal ArticleDOI
Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma
Xiao Hong Ma,Sheng Fu Piao,Souvik Dey,Quentin McAfee,Giorgos C. Karakousis,Jessie Villanueva,Lori S. Hart,Samuel M. Levi,Janice Hu,Gao Zhang,Rossitza Lazova,Vincent Klump,John M. Pawelek,Xiaowei Xu,Wei Xu,Lynn M. Schuchter,Michael A. Davies,Meenhard Herlyn,Jeffrey D. Winkler,Constantinos Koumenis,Ravi K. Amaravadi +20 more
TL;DR: Using tumor biopsies from BRAF(V600E) melanoma patients treated either with BRAFi or with combined BRAF and MEK inhibition, it is found that BRAFi-resistant tumors had increased levels of autophagy compared with baseline and a rationale for combination approaches targeting this resistance pathway is provided.
Journal ArticleDOI
Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency
Quentin McAfee,Zhihui Zhang,Arabinda Samanta,Samuel M. Levi,Xiao Hong Ma,Shengfu Piao,John P. Lynch,Takeshi Uehara,Antonia R. Sepulveda,Lisa E. Davis,Jeffrey D. Winkler,Ravi K. Amaravadi +11 more
TL;DR: B bisaminoquinoline autophagy inhibitors are synthesized and characterization and significant single-agent antitumor activity is observed without toxicity in mice treated with lower doses of Lys05, establishing the therapeutic potential of this compound in cancer.
Journal ArticleDOI
A unified approach to targeting the lysosome’s degradative and growth signaling roles
Vito W. Rebecca,Michael C. Nicastri,Noel P. McLaughlin,Colin Fennelly,Quentin McAfee,Amruta Ronghe,Michel Nofal,Chun Yan Lim,Eric S. Witze,Cynthia I. Chude,Gao Zhang,Gretchen M. Alicea,Shengfu Piao,Sengottuvelan Murugan,Rani Ojha,Samuel M. Levi,Zhi Wei,Julie S. Barber-Rotenberg,Maureen E. Murphy,Gordon B. Mills,Yiling Lu,Joshua D. Rabinowitz,Ronen Marmorstein,Qin Liu,Shujing Liu,Xiaowei Xu,Meenhard Herlyn,Roberto Zoncu,Donita C. Brady,David W. Speicher,Jeffrey D. Winkler,Ravi K. Amaravadi +31 more
TL;DR: Chemical features of dimeric compounds that increase their lysosomal specificity, and a new molecular target for these compounds, reclassifying these compounds as targeted therapies are identified, providing a new strategy for cancer therapy.
Journal ArticleDOI
Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells
Vanessa M. Hubbard-Lucey,Yusuke Shono,Katie Maurer,Mallory L. West,Natalie V. Singer,Carly G. K. Ziegler,Cecilia Lezcano,Ana Carolina Fragoso Motta,Karin Schmid,Samuel M. Levi,George F. Murphy,Chen Liu,Jeffrey D. Winkler,Ravi K. Amaravadi,Gerhard Rogler,Anne M. Dickinson,Ernst Holler,Marcel R.M. van den Brink,Ken Cadwell +18 more
TL;DR: The function of Atg16L1 and the autophagy pathway is broadened to include a role in limiting a DC-mediated response during inflammatory disease, such as GVHD.
Journal ArticleDOI
Palladium-Catalyzed C−CN Activation for Intramolecular Cyanoesterification of Alkynes
Naveen R. Rondla,Samuel M. Levi,Jonathan M. Ryss,Rachel A. Vanden Berg,Christopher J. Douglas +4 more
TL;DR: The results led to the hypothesis that migratory insertion of the alkyne, rather than C-CN activation, might be the product-determining step.