G
Gretchen M. Alicea
Researcher at Wistar Institute
Publications - 29
Citations - 1125
Gretchen M. Alicea is an academic researcher from Wistar Institute. The author has contributed to research in topics: Melanoma & Medicine. The author has an hindex of 11, co-authored 17 publications receiving 653 citations. Previous affiliations of Gretchen M. Alicea include Johns Hopkins University & Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations
Curtis H. Kugel,Stephen M. Douglass,Marie R. Webster,Amanpreet Kaur,Amanpreet Kaur,Qin Liu,Xiangfan Yin,Sarah A. Weiss,Farbod Darvishian,Rami N. Al-Rohil,Abibatou Ndoye,Abibatou Ndoye,Reeti Behera,Gretchen M. Alicea,Gretchen M. Alicea,Brett L. Ecker,Mitchell Fane,Michael J. Allegrezza,Nikolaos Svoronos,Vinit Kumar,Daniel Y. Wang,Rajasekharan Somasundaram,Siwen Hu-Lieskovan,Alpaslan Özgün,Meenhard Herlyn,Jose R. Conejo-Garcia,Dmitry I. Gabrilovich,Eric A. Stone,Theodore S. Nowicki,Jeffrey A. Sosman,Rajat Rai,Matteo S. Carlino,Georgina V. Long,Richard Marais,Antoni Ribas,Zeynep Eroglu,Michael A. Davies,Bastian Schilling,Dirk Schadendorf,Wei Xu,Ravi K. Amaravadi,Alexander M. Menzies,Jennifer L. McQuade,Douglas B. Johnson,Iman Osman,Ashani T. Weeraratna +45 more
TL;DR: These data suggest that this increased response in aged patients occurs even in the absence of a more complex mutational landscape, and stress the importance of considering age as a factor for immunotherapy response.
Journal ArticleDOI
PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer.
Vito W. Rebecca,Michael C. Nicastri,Colin Fennelly,Cynthia I. Chude,Julie S. Barber-Rotenberg,Amruta Ronghe,Quentin McAfee,Noel P. McLaughlin,Gao Zhang,Aaron R. Goldman,Rani Ojha,Shengfu Piao,Estela Noguera-Ortega,Alessandra Martorella,Gretchen M. Alicea,Jennifer J. Lee,Lynn M. Schuchter,Xiaowei Xu,Meenhard Herlyn,Ronen Marmorstein,Phyllis A. Gimotty,David W. Speicher,Jeffrey D. Winkler,Ravi K. Amaravadi +23 more
TL;DR: A novel dimeric CQ (DC661) capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ) is reported, providing a strong rationale for targeting PPT1 in cancer.
Journal ArticleDOI
A unified approach to targeting the lysosome’s degradative and growth signaling roles
Vito W. Rebecca,Michael C. Nicastri,Noel P. McLaughlin,Colin Fennelly,Quentin McAfee,Amruta Ronghe,Michel Nofal,Chun Yan Lim,Eric S. Witze,Cynthia I. Chude,Gao Zhang,Gretchen M. Alicea,Shengfu Piao,Sengottuvelan Murugan,Rani Ojha,Samuel M. Levi,Zhi Wei,Julie S. Barber-Rotenberg,Maureen E. Murphy,Gordon B. Mills,Yiling Lu,Joshua D. Rabinowitz,Ronen Marmorstein,Qin Liu,Shujing Liu,Xiaowei Xu,Meenhard Herlyn,Roberto Zoncu,Donita C. Brady,David W. Speicher,Jeffrey D. Winkler,Ravi K. Amaravadi +31 more
TL;DR: Chemical features of dimeric compounds that increase their lysosomal specificity, and a new molecular target for these compounds, reclassifying these compounds as targeted therapies are identified, providing a new strategy for cancer therapy.
Journal ArticleDOI
HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci.
Katherine M. Aird,Osamu Iwasaki,Andrew V. Kossenkov,Hideki Tanizawa,Nail Fatkhutdinov,Nail Fatkhutdinov,Benjamin G. Bitler,Linh Le,Linh Le,Gretchen M. Alicea,Ting-Lin B. Yang,F. Brad Johnson,Ken-ichi Noma,Rugang Zhang +13 more
TL;DR: It is shown that the chromatin-bound protein HMGB2 orchestrates the SASP by preventing heterochromatin spreading to these specific loci.
Journal ArticleDOI
Age-Related Changes in HAPLN1 Increase Lymphatic Permeability and Affect Routes of Melanoma Metastasis
Brett L. Ecker,Brett L. Ecker,Amanpreet Kaur,Amanpreet Kaur,Stephen M. Douglass,Marie R. Webster,Filipe V. Almeida,Gloria Marino,Gloria Marino,Andrew J. Sinnamon,Madalyn G. Neuwirth,Gretchen M. Alicea,Gretchen M. Alicea,Abibatou Ndoye,Abibatou Ndoye,Mitchell Fane,Xiaowei Xu,Myung-Shin Sim,Gary B. Deutsch,Mark B. Faries,Giorgos C. Karakousis,Ashani T. Weeraratna +21 more
TL;DR: The studies reveal that changes in the stroma during aging may influence the way tumor cells traffic through the lymphatic vasculature, and suggest that age-related changes in ECM can contribute to impaired lymphatics.