D
Donita C. Brady
Researcher at University of Pennsylvania
Publications - 50
Citations - 2841
Donita C. Brady is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 17, co-authored 36 publications receiving 1637 citations. Previous affiliations of Donita C. Brady include Duke University & University of North Carolina at Chapel Hill.
Papers
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Journal ArticleDOI
Copper is required for oncogenic BRAF signalling and tumorigenesis
Donita C. Brady,Matthew S. Crowe,Michelle L. Turski,G. Aaron Hobbs,Xiaojie Yao,Apirat Chaikuad,Stefan Knapp,Kunhong Xiao,Sharon L. Campbell,Dennis J. Thiele,Christopher M. Counter +10 more
TL;DR: In this paper, the levels of CTR1 (cu transporter 1), or mutations in MEK1 that disrupt Cu binding, decreased BRAF(V600E)-driven signalling and tumorigenesis in mice and human cell settings.
Journal Article
Copper is required for oncogenic BRAF signaling and tumorigenesis
Donita C. Brady,Matthew S. Crowe,Michelle L. Turski,G A Hobbs,Apirat Chaikuad,Stefan Knapp,Sharon L. Campbell,Dennis J. Thiele,Christopher M. Counter +8 more
Journal ArticleDOI
Connecting copper and cancer: from transition metal signalling to metalloplasia.
Eva J Ge,Ashley I. Bush,Angela Casini,Paul A. Cobine,Justin R. Cross,Gina M. DeNicola,Q Ping Dou,Katherine J. Franz,Vishal M. Gohil,Sanjeev Gupta,Stephen G. Kaler,Svetlana Lutsenko,Vivek Mittal,Michael J. Petris,Roman S. Polishchuk,Martina Ralle,Michael L. Schilsky,Nicholas K. Tonks,Linda T. Vahdat,Linda Van Aelst,Dan Xi,Peng Yuan,Donita C. Brady,Christopher J. Chang +23 more
TL;DR: In this article, the authors summarize the current understanding of the connection between copper and cancer and explore how challenges in the field could be addressed by using the framework of cuproplasia, which is defined as regulated copper-dependent cell proliferation and is a representative example of a broad range of metalloplasias.
Journal ArticleDOI
RALA and RALBP1 regulate mitochondrial fission at mitosis
David F. Kashatus,Kian-Huat Lim,Kian-Huat Lim,Donita C. Brady,Donita C. Brady,Nicole L.K. Pershing,Adrienne D. Cox,Christopher M. Counter +7 more
TL;DR: The two mitotic kinases Aurora A and cyclin B–CDK1 converge on RALA and RALBP1 to promote mitochondrial fission, the appropriate distribution of mitochondria to daughter cells and ultimately proper mitochondrial function.
Journal ArticleDOI
A novel role for copper in Ras/mitogen-activated protein kinase signaling.
Michelle L. Turski,Donita C. Brady,Hyung J. Kim,Byung-Eun Kim,Yasuhiro Nose,Christopher M. Counter,Dennis R. Winge,Dennis J. Thiele +7 more
TL;DR: Coimmunoprecipitation experiments suggest that Cu is important for promoting the Mek1-Erk physical interaction that precedes the phosphorylation of Erk by Mek1 in a dose-dependent fashion.