Sandra Lettlova

TL;DR: It is found that alteration of the pyruvate-lactate axis is a fundamental and early feature of cardiac hypertrophy and failure.

TL;DR: Genetic studies in Drosophila suggest that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation, and loss of Mpc1 prior to a tumorigenic stimulus doubled the frequency of adenoma formation and produced higher grade tumors.

TL;DR: It is shown that hypomorphic mtFAS mutant mouse skeletal myoblast cell lines display a severe loss of electron transport chain (ETC) complexes and exhibit compensatory metabolic activities including reductive carboxylation, suggesting that ETC activity in mammals is profoundly controlled bymtFAS function.

TL;DR: In this article, the authors investigated the fate of peroxisomal mRNAs and proteins in Zellweger spectrum disorder (ZSD) model systems and found that peroxins were still expressed and a subset of them accumulated on the mitochondrial membrane, which resulted in gross mitochondrial abnormalities and impaired mitochondrial metabolic function.

TL;DR: It is found that loss of peroxisomal import has no effect on peroxin mRNA expression or translational efficiency, and mitochondrial function is rescued in fibroblasts derived from human patients with ZSD by overexpressing ATAD1, an AAA-ATPase that functions in mitochondrial quality control.