Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Claire L. Bensard,Dona R. Wisidagama,Kristofor A. Olson,Jordan A. Berg,Nathan M. Krah,John C. Schell,Sara M. Nowinski,Sarah Fogarty,Alex J. Bott,Peng Wei,Katja K. Dove,Jason M. Tanner,Vanja Panic,Ahmad A. Cluntun,Sandra Lettlova,Christian S. Earl,David F. Namnath,Karina Vázquez-Arreguín,Claudio J. Villanueva,Dean Tantin,L. Charles Murtaugh,Kimberley J. Evason,Kimberley J. Evason,Gregory S. Ducker,Carl S. Thummel,Jared Rutter +25 more
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TLDR
Genetic studies in Drosophila suggest that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation, and loss of Mpc1 prior to a tumorigenic stimulus doubled the frequency of adenoma formation and produced higher grade tumors.About:
This article is published in Cell Metabolism.The article was published on 2020-02-04 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Tumor initiation & Glycolysis.read more
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Glutamine reliance in cell metabolism.
TL;DR: This review introduces the various biosynthetic and bioenergetic roles of glutamine based on the compartmentalization of glutamines metabolism to explain why cells exhibit metabolic reliance on glutamine and proposes a metabolic target for therapeutic intervention in cancer.
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Mitochondrial DNA copy number in human disease: the more the better?
Roberta Filograna,Roberta Filograna,Mara Mennuni,Mara Mennuni,David Alsina,David Alsina,Nils-Göran Larsson,Nils-Göran Larsson +7 more
TL;DR: Current knowledge of the role of mtDNA copy number regulation in various types of human diseases, including mitochondrial disorders, neurodegenerative disorders and cancer, and during ageing is critically discussed.
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
TL;DR: An independent approach based solely on cancer genome sequencing and epidemiological data suggested that R mutations are responsible for two-thirds of the mutations in human cancers, and results are consistent with epidemiological estimates of the fraction of cancers that can be prevented by changes in the environment.
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The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.
Ahmad A. Cluntun,Rachit Badolia,Sandra Lettlova,K. Mark Parnell,Thirupura S. Shankar,Nikolaos A. Diakos,Kristofor A. Olson,Iosif Taleb,Sean M. Tatum,Jordan A. Berg,Corey N. Cunningham,Tyler Van Ry,Alex J. Bott,Aspasia Thodou Krokidi,Sarah Fogarty,Sophia Skedros,Wojciech I. Swiatek,Xuejing Yu,Bai Luo,Shannon Merx,Sutip Navankasattusas,James E. Cox,Gregory S. Ducker,William L. Holland,Stephen H. McKellar,Stephen H. McKellar,Jared Rutter,Stavros G. Drakos,Stavros G. Drakos +28 more
TL;DR: It is found that alteration of the pyruvate-lactate axis is a fundamental and early feature of cardiac hypertrophy and failure.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Journal ArticleDOI
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists
TL;DR: The survey will help tool designers/developers and experienced end users understand the underlying algorithms and pertinent details of particular tool categories/tools, enabling them to make the best choices for their particular research interests.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.