J. Alan Maschek

TL;DR: Mechanistic studies revealed ceramide actions that promoted lipid uptake and storage and impaired glucose utilization, none of which could be recapitulated by (dihydro)ceramides that lacked the critical double bond, suggest that inhibition of DES1 may provide a means of treating hepatic steatosis and metabolic disorders.

TL;DR: It is reported here that activation of immunity causes an energetic trade-off with the homeothermy (the stable maintenance of core temperature), resulting in hypometabolism and hypothermia, suggesting that energy-conserving hypometabolic states, such as dormancy, might have evolved as a mechanism of tissue tolerance.

TL;DR: Poly rC binding protein 1 (PCBP1) is a multifunctional protein that serves as a cytosolic iron chaperone, binding and transferring iron to recipient proteins in mammalian cells.

TL;DR: This chapter is intended as an overview of natural product chemistry with an emphasis on the chemical aspects of algal defensive metabolites, and it is hoped that algal ecologists will gain insight into the chemistry in the same manner that chemists will acquire a deeper understanding of the ecology from the remaining chapters of this book.

TL;DR: It is demonstrated that the mitochondrial groups in D. kerguelenensis also correlate with nuclear DNA, and the strong linkage between these metabolites and the mitochondrial lineages strongly suggests that these lineages represent cryptic species in an adaptive radiation.