S
Sandra Lettlova
Researcher at University of Utah
Publications - 7
Citations - 259
Sandra Lettlova is an academic researcher from University of Utah. The author has contributed to research in topics: Mitochondrion & Citric acid cycle. The author has an hindex of 3, co-authored 7 publications receiving 88 citations.
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Journal ArticleDOI
The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.
Ahmad A. Cluntun,Rachit Badolia,Sandra Lettlova,K. Mark Parnell,Thirupura S. Shankar,Nikolaos A. Diakos,Kristofor A. Olson,Iosif Taleb,Sean M. Tatum,Jordan A. Berg,Corey N. Cunningham,Tyler Van Ry,Alex J. Bott,Aspasia Thodou Krokidi,Sarah Fogarty,Sophia Skedros,Wojciech I. Swiatek,Xuejing Yu,Bai Luo,Shannon Merx,Sutip Navankasattusas,James E. Cox,Gregory S. Ducker,William L. Holland,Stephen H. McKellar,Stephen H. McKellar,Jared Rutter,Stavros G. Drakos,Stavros G. Drakos +28 more
TL;DR: It is found that alteration of the pyruvate-lactate axis is a fundamental and early feature of cardiac hypertrophy and failure.
Journal ArticleDOI
Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.
Claire L. Bensard,Dona R. Wisidagama,Kristofor A. Olson,Jordan A. Berg,Nathan M. Krah,John C. Schell,Sara M. Nowinski,Sarah Fogarty,Alex J. Bott,Peng Wei,Katja K. Dove,Jason M. Tanner,Vanja Panic,Ahmad A. Cluntun,Sandra Lettlova,Christian S. Earl,David F. Namnath,Karina Vázquez-Arreguín,Claudio J. Villanueva,Dean Tantin,L. Charles Murtaugh,Kimberley J. Evason,Kimberley J. Evason,Gregory S. Ducker,Carl S. Thummel,Jared Rutter +25 more
TL;DR: Genetic studies in Drosophila suggest that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation, and loss of Mpc1 prior to a tumorigenic stimulus doubled the frequency of adenoma formation and produced higher grade tumors.
Journal ArticleDOI
Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria.
Sara M. Nowinski,Ashley Solmonson,Scott F. Rusin,J. Alan Maschek,Claire L. Bensard,Sarah Fogarty,Mi Young Jeong,Sandra Lettlova,Jordan A. Berg,Jeffrey T. Morgan,Yeyun Ouyang,Bradley C. Naylor,Joao A. Paulo,Katsuhiko Funai,James E. Cox,Steven P. Gygi,Dennis R. Winge,Ralph J. DeBerardinis,Ralph J. DeBerardinis,Jared Rutter +19 more
TL;DR: It is shown that hypomorphic mtFAS mutant mouse skeletal myoblast cell lines display a severe loss of electron transport chain (ETC) complexes and exhibit compensatory metabolic activities including reductive carboxylation, suggesting that ETC activity in mammals is profoundly controlled bymtFAS function.
Journal ArticleDOI
The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder.
Esther Nuebel,Esther Nuebel,Esther Nuebel,Jeffrey T. Morgan,Jeffrey T. Morgan,Sarah Fogarty,Sarah Fogarty,Jacob M. Winter,Sandra Lettlova,Jordan A. Berg,Yu-Chan Chen,Chelsea U Kidwell,J. Alan Maschek,Katie J. Clowers,Catherine Argyriou,Lingxiao Chen,Ilka Wittig,James E. Cox,Minna Roh-Johnson,Nancy Braverman,Nancy Braverman,Joshua L. Bonkowsky,Steven P. Gygi,Jared Rutter,Jared Rutter +24 more
TL;DR: In this article, the authors investigated the fate of peroxisomal mRNAs and proteins in Zellweger spectrum disorder (ZSD) model systems and found that peroxins were still expressed and a subset of them accumulated on the mitochondrial membrane, which resulted in gross mitochondrial abnormalities and impaired mitochondrial metabolic function.
Posted ContentDOI
Msp1/ATAD1 restores mitochondrial function in Zellweger Spectrum Disease
Esther Nuebel,Jeffrey T. Morgan,Sarah Fogarty,Jacob M. Winter,Sandra Lettlova,Jordan A. Berg,Yu-Chan Chen,Chelsea U Kidwell,J. Alan Maschek,Katie J. Clowers,Catherine Argyriou,Lingxiao Chen,Ilka Wittig,James E. Cox,Minna Roh-Johnson,Nancy Braverman,Steven J. Steinberg,Steven P. Gygi,Jared Rutter +18 more
TL;DR: It is found that loss of peroxisomal import has no effect on peroxin mRNA expression or translational efficiency, and mitochondrial function is rescued in fibroblasts derived from human patients with ZSD by overexpressing ATAD1, an AAA-ATPase that functions in mitochondrial quality control.